{"id":"W6990591389","doi":"","title":"Donepezil-Loaded Nanocarriers for the Treatment of Alzheimer&amp;amp;rsquo;s Disease: Superior Efficacy of Extracellular Vesicles Over Polymeric Nanoparticles","year":2024,"lang":"en","type":"other","venue":"Dove Medical Press (Taylor and Francis Group)","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada; Connaught Fund; Armand-Frappier Foundation","keywords":"Nanocarriers; Transcytosis; Drug; In vitro; Blood–brain barrier; Drug delivery; Pharmaceutical sciences; Drug carrier","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002240463,0.0003465099,0.0003612508,0.0001674816,0.0001184143,0.0004610924,0.0002092541,0.0004734024,0.0009787322],"category_scores_gemma":[0.0002066746,0.0001303759,0.0003762456,0.0001023483,0.0001554772,0.0004017427,0.0002419568,0.0004152216,0.0003664272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002893401,"about_ca_system_score_gemma":0.0001775617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008988206,"about_ca_topic_score_gemma":0.00121583,"domain_scores_codex":[0.9998999,0.00001781945,0.000007056362,0.00002713227,0.00002337692,0.00002475178],"domain_scores_gemma":[0.9999417,0.00001490485,0.000014335,0.000004731095,0.0000127172,0.00001164694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009796462,0.0001196422,0.00009133902,0.0002993934,0.00003986065,0.000119033,0.00005599963,0.0002607059,0.9773638,0.0002436976,0.0003917296,0.02003511],"study_design_scores_gemma":[0.0001412676,0.001512683,0.0009617984,0.00003270575,0.0001059664,0.0002754884,0.00003419071,0.002451969,0.9876913,0.00006907259,0.006701251,0.00002233275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9650888,0.02354069,0.006219335,0.0003642804,0.0002619478,0.0001075967,0.0002198305,0.0001702662,0.004027092],"genre_scores_gemma":[0.9869573,0.005405949,0.003366074,0.0001407725,0.00002782264,0.00006499976,0.0001483536,0.00003921571,0.003849512],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.0009787322,"threshold_uncertainty_score":0.003274202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08764781973734574,"score_gpt":0.3920995938705938,"score_spread":0.304451774133248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}