{"id":"W6990656046","doi":"","title":"Effects of roflumilast in COPD patients receiving inhaled corticosteroid/long-acting &amp;amp;beta;2-agonist fixed-dose combination: RE2SPOND rationale and study design","year":2016,"lang":"en","type":"other","venue":"Dove Medical Press (Taylor and Francis Group)","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Allergan; National Institutes of Health; Veracyte; Bundesministerium für Bildung und Forschung; GlaxoSmithKline; Biogen; Sunovion; Gilead Sciences; Genentech; AstraZeneca; American Thoracic Society","keywords":"Chronic bronchitis; COPD; Roflumilast; Veterans Affairs; Bronchitis; Health care","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003769066,0.002490834,0.004942599,0.000845662,0.0009612522,0.001346206,0.001781389,0.002353122,0.006966005],"category_scores_gemma":[0.002674021,0.0009946048,0.00318298,0.0009256657,0.001871126,0.001340791,0.0009899121,0.002578519,0.001367998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001452668,"about_ca_system_score_gemma":0.002970098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000651213,"about_ca_topic_score_gemma":0.001424407,"domain_scores_codex":[0.9972524,0.001204373,0.0002962969,0.0005302459,0.0003090438,0.0004076761],"domain_scores_gemma":[0.9987363,0.000289494,0.0002794477,0.0001715056,0.0001186449,0.0004045626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9059789,0.03155392,0.009601832,0.002091571,0.001109894,0.0002461562,0.0001561974,0.0004930352,0.007702728,0.00047037,0.0008349551,0.03976038],"study_design_scores_gemma":[0.4521519,0.5044574,0.02760718,0.0003594237,0.002692491,0.0002673977,0.0001805735,0.001126593,0.002769248,0.0007345795,0.007506045,0.0001470869],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.8908091,0.01225247,0.002362016,0.000969475,0.0009438785,0.08138359,0.00297313,0.00009080373,0.008215658],"genre_scores_gemma":[0.8644503,0.005565428,0.007244959,0.002936749,0.001840068,0.1086286,0.002517954,0.00005564775,0.006760283],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.006966005,"threshold_uncertainty_score":0.02330357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307599440853302,"score_gpt":0.2545985019315905,"score_spread":0.2415225075230575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}