{"id":"W6995803029","doi":"","title":"Phenome-wide, Metabolomic and Proteomic Association Scan of SHROOM3 Haplotypes Based on Imputed Exonic Variants","year":2023,"lang":"en","type":"article","venue":"View","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; School of Medicine, Indiana University; University of North Carolina at Chapel Hill; University of Texas MD Anderson Cancer Center; University of Washington; College of Engineering, Michigan State University; School of Medicine, University of North Carolina at Chapel Hill; State Key Laboratory of Oncology in South China; Shenzhen Research Institute, City University of Hong Kong; Michigan State University; National Taiwan University; National Taiwan University Hospital; Chinese University of Hong Kong; Sun Yat-sen University; Curtin University of Technology; Perelman School of Medicine, University of Pennsylvania; Vanderbilt University Medical Center; Sun Yat-sen University Cancer Center; School of Medicine, Case Western Reserve University; Commonwealth of Kentucky; Rush University; Wayne State University; Harvard T.H. Chan School of Public Health; Pennsylvania State University; Leonard M. Miller School of Medicine; University of Toronto; Case Western Reserve University; Institute for Translational Medicine and Therapeutics; Vanderbilt University; University of Pennsylvania; Carolina Population Center, University of North Carolina at Chapel Hill; University of Miami","keywords":"Haplotype; Genetic variants; Genetic association; Genome-wide association study; Gene; Kidney disease; Single-nucleotide polymorphism; Association (psychology); Metabolomics; Proteomics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002474262,0.00008390161,0.0001285856,0.00005645103,0.00004442942,0.00001069045,0.00004514904,0.00008962239,0.00002208481],"category_scores_gemma":[0.0001021164,0.00007335506,0.00004335192,0.0001505884,0.00001755562,0.000003472923,0.0000265664,0.00003647864,0.00001969323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002287498,"about_ca_system_score_gemma":0.00005284496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009441222,"about_ca_topic_score_gemma":0.000008149061,"domain_scores_codex":[0.999401,0.00006259452,0.0001462148,0.0001836547,0.00009161411,0.0001149098],"domain_scores_gemma":[0.9996437,0.00002013308,0.0001109196,0.0001477942,0.00004540728,0.00003203738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002753035,0.0001139187,0.02354217,0.0001786965,0.0001818496,0.000001459815,0.0000537276,0.001016965,0.95101,0.0001746249,0.00557964,0.01787168],"study_design_scores_gemma":[0.001681978,0.0004452219,0.734884,0.0001061482,0.0000806655,0.000001410468,0.00001408997,0.007084693,0.2304985,0.000194079,0.02473124,0.0002779174],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977089,0.0006359936,0.0004838153,0.0003696171,0.0001910208,0.000267241,0.00001984344,0.00002965729,0.0002938973],"genre_scores_gemma":[0.9983045,0.0004165178,0.0001513079,0.0002499819,0.00005487119,0.00002338173,0.0001382147,0.00001287213,0.0006482836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7205114,"threshold_uncertainty_score":0.2991332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008112269458607654,"score_gpt":0.2261005655533843,"score_spread":0.2179882960947767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}