{"id":"W6995803029","doi":"","title":"Phenome-wide, Metabolomic and Proteomic Association Scan of SHROOM3 Haplotypes Based on Imputed Exonic Variants","year":2023,"lang":"en","type":"article","venue":"View","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; School of Medicine, Indiana University; University of North Carolina at Chapel Hill; University of Texas MD Anderson Cancer Center; University of Washington; College of Engineering, Michigan State University; School of Medicine, University of North Carolina at Chapel Hill; State Key Laboratory of Oncology in South China; Shenzhen Research Institute, City University of Hong Kong; Michigan State University; National Taiwan University; National Taiwan University Hospital; Chinese University of Hong Kong; Sun Yat-sen University; Curtin University of Technology; Perelman School of Medicine, University of Pennsylvania; Vanderbilt University Medical Center; Sun Yat-sen University Cancer Center; School of Medicine, Case Western Reserve University; Commonwealth of Kentucky; Rush University; Wayne State University; Harvard T.H. Chan School of Public Health; Pennsylvania State University; Leonard M. Miller School of Medicine; University of Toronto; Case Western Reserve University; Institute for Translational Medicine and Therapeutics; Vanderbilt University; University of Pennsylvania; Carolina Population Center, University of North Carolina at Chapel Hill; University of Miami","keywords":"Haplotype; Genetic variants; Genetic association; Genome-wide association study; Gene; Kidney disease; Single-nucleotide polymorphism; Association (psychology); Metabolomics; Proteomics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003624299,0.0003044098,0.0003158236,0.0005705701,0.0004555045,0.0002671543,0.0002028368,0.0003211685,0.001841243],"category_scores_gemma":[0.000617841,0.0001188707,0.0004496814,0.0008656456,0.0001981332,0.0001109346,0.0003802024,0.0003304364,0.000122765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001540772,"about_ca_system_score_gemma":0.000200634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006325271,"about_ca_topic_score_gemma":0.01267087,"domain_scores_codex":[0.9997585,0.00004973947,0.00002100586,0.0001084923,0.00002331616,0.0000389442],"domain_scores_gemma":[0.9997119,0.0000825344,0.00008188517,0.00003112368,0.00003295857,0.00005946153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002558422,0.00008361661,0.9331206,0.00008303129,0.0008711399,0.001625413,0.0003698863,0.0005654946,0.05244037,0.0002140179,0.0008071073,0.007260839],"study_design_scores_gemma":[0.00005212146,0.0001578477,0.9956464,0.00001305508,0.0003130683,0.0009477053,0.000125105,0.0006040815,0.00132885,0.0001231015,0.0006802304,0.000008369686],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997844,0.0001242008,0.0004894469,0.00003810542,0.000003313223,0.000007428507,0.001317396,0.000007561481,0.0001685872],"genre_scores_gemma":[0.9978016,0.0000544471,0.0007281725,0.00003011021,0.00000443136,0.00001638591,0.001100498,0.000006993776,0.000257362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006325271,"threshold_uncertainty_score":0.01257694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008112269458607654,"score_gpt":0.2261005655533843,"score_spread":0.2179882960947767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}