{"id":"W6996521176","doi":"","title":"Simulation of the coupling between nucleotide binding and transmembrane domains in the ABC transporter BtuCD","year":2007,"lang":"en","type":"article","venue":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"ATP-binding cassette transporter; Coupling (piping); Transmembrane domain; Transmembrane protein; Domain (mathematical analysis); Nucleotide; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003543446,0.0004750705,0.00112661,0.000507014,0.001162585,0.00109125,0.001240277,0.002126861,0.006262832],"category_scores_gemma":[0.001783433,0.0005401789,0.0007367739,0.0007331487,0.001143939,0.0007363748,0.0006896349,0.001299591,0.0002466008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002614449,"about_ca_system_score_gemma":0.002294854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05702766,"about_ca_topic_score_gemma":0.02007467,"domain_scores_codex":[0.9997846,0.00004368576,0.000007734696,0.00002757051,0.00004207843,0.00009426078],"domain_scores_gemma":[0.9988167,0.0007391623,0.00006232398,0.0000532976,0.0001347993,0.0001937629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004250094,0.0001783258,0.003176643,0.00008343613,0.00006360168,0.00031219,0.0001282484,0.9837765,0.003140633,0.006263881,0.0007888165,0.001662849],"study_design_scores_gemma":[0.0001032276,0.00006097713,0.0006807978,0.000008717773,0.00001266207,0.00001452604,0.00005396502,0.9976689,0.0005255067,0.0006011963,0.00025947,0.00000999226],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876987,0.0001963677,0.002426337,0.0005812321,0.00005567053,0.00001901455,0.0003150584,0.00008016113,0.008627374],"genre_scores_gemma":[0.9972506,0.00009788342,0.001309859,0.00008867429,0.000009386727,0.00002520314,0.0002137471,0.00002291854,0.0009817722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05702766,"threshold_uncertainty_score":0.1133915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491289629474407,"score_gpt":0.229881816080287,"score_spread":0.2149689197855429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}