{"id":"W6996549182","doi":"","title":"Small molecule restores itaconate sensitivity in Salmonella enterica: a potential new approach to treat bacterial infections","year":2016,"lang":"en","type":"article","venue":"eScholarship@McGill (McGill)","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Salmonella enterica; Context (archaeology); Antibiotics; Salmonella; Antimicrobial; Small molecule; Intracellular; Antibiotic resistance; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003549004,0.000385887,0.0003153379,0.000172055,0.0002656925,0.00004554355,0.0002445402,0.0003392347,0.00003634534],"category_scores_gemma":[0.0002607939,0.0003399792,0.0001964304,0.0002665845,0.00007319668,0.00002163548,0.0002878622,0.0002058379,0.0001051756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001743787,"about_ca_system_score_gemma":0.00006591346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003926869,"about_ca_topic_score_gemma":0.001840548,"domain_scores_codex":[0.9975716,0.0003034402,0.0003897695,0.0008939258,0.000214107,0.0006271693],"domain_scores_gemma":[0.9987701,0.00002997943,0.0001087642,0.0006355697,0.0001232048,0.0003324507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000448441,0.0002609009,0.0002345089,0.00001595967,0.00004858195,0.0000435582,0.000003153651,0.00009226376,0.9882174,0.0006129824,0.00005054894,0.009971774],"study_design_scores_gemma":[0.001947774,0.000428642,0.005541911,0.00004812987,0.00004873949,0.0001032861,0.00001728187,0.000006666588,0.9580711,0.0005708112,0.0325675,0.000648146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870585,0.00005143201,0.000108819,0.00006015591,0.0003085849,0.0003848067,0.0003031003,0.00004403099,0.01168055],"genre_scores_gemma":[0.9947536,0.00013653,0.001280039,0.0002738432,0.0001824443,0.0000480929,0.00007874463,0.00007076951,0.003175956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03251695,"threshold_uncertainty_score":0.9999052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511762756660603,"score_gpt":0.2175562366570842,"score_spread":0.2024386090904782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}