{"id":"W6996549182","doi":"","title":"Small molecule restores itaconate sensitivity in Salmonella enterica: a potential new approach to treat bacterial infections","year":2016,"lang":"en","type":"article","venue":"eScholarship@McGill (McGill)","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Salmonella enterica; Context (archaeology); Antibiotics; Salmonella; Antimicrobial; Small molecule; Intracellular; Antibiotic resistance; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008840419,0.0002926128,0.0002281692,0.0002435859,0.0001083935,0.0002291383,0.0002277973,0.0002859197,0.00151734],"category_scores_gemma":[0.00004006816,0.00007971496,0.0002119246,0.00009795966,0.0002167085,0.0001220927,0.0001484963,0.0004631803,0.000286707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002394646,"about_ca_system_score_gemma":0.0002193046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006476923,"about_ca_topic_score_gemma":0.00160497,"domain_scores_codex":[0.9999608,0.000005800216,0.000003129614,0.000005072101,0.00001042876,0.00001487633],"domain_scores_gemma":[0.9999735,0.000002356746,0.00000792315,0.00000319974,0.000004601742,0.000008392955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001161789,0.00004736132,0.00009639619,0.00004779153,0.000005149047,0.00005620456,0.000006824867,0.00005805243,0.9938201,0.0001859755,0.0001026375,0.005457335],"study_design_scores_gemma":[0.0001349391,0.00316354,0.005856818,0.00002478586,0.00005723161,0.000610506,0.00003944921,0.0005557244,0.9711382,0.0001586235,0.01824743,0.00001275567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800514,0.008807538,0.004229316,0.0009581627,0.000156809,0.0001094474,0.0003324959,0.0003536028,0.005001189],"genre_scores_gemma":[0.9796385,0.00799344,0.003975518,0.0003200799,0.00004093457,0.00004945946,0.0003339426,0.00003152232,0.007616479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00151734,"threshold_uncertainty_score":0.005075932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511762756660603,"score_gpt":0.2175562366570842,"score_spread":0.2024386090904782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}