{"id":"W6996957086","doi":"","title":"Therapeutic potential of LY-404,039 via activation of mGluR2/3 in Parkinson’s disease","year":2023,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Parkinson Canada; Weston Brain Institute; Biogen; Sunovion; Michael J. Fox Foundation for Parkinson's Research","keywords":"Disease; Immune system; Identification (biology); Product (mathematics); Action (physics)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001652754,0.0002239079,0.0002208322,0.0001805532,0.0001708246,0.0003028206,0.0002051721,0.0003252615,0.01272049],"category_scores_gemma":[0.0001038299,0.00007112005,0.0002166194,0.0001217096,0.00009566518,0.0001650938,0.0002215858,0.0005614303,0.002478681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000212451,"about_ca_system_score_gemma":0.0004928238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005994632,"about_ca_topic_score_gemma":0.001278236,"domain_scores_codex":[0.9999608,0.000008217418,0.000001939639,0.000004740666,0.000009136662,0.00001516601],"domain_scores_gemma":[0.9999834,0.000002546827,0.000002595949,8.23263e-7,0.000003701591,0.000006833788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005447675,0.001548112,0.0003774025,0.001180184,0.00009645727,0.0004669572,0.000161394,0.0009009037,0.6084692,0.005146363,0.01805229,0.3581531],"study_design_scores_gemma":[0.00713332,0.02449238,0.02496358,0.001014745,0.0003656158,0.001993131,0.0005119511,0.00347833,0.4977202,0.00580012,0.4324308,0.00009580175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7398442,0.07077377,0.005149034,0.007990815,0.0009565162,0.0006608496,0.001958948,0.0006996411,0.1719662],"genre_scores_gemma":[0.8077752,0.05461656,0.006322677,0.001845312,0.0002652703,0.0003978363,0.001251741,0.00008338706,0.1274421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01272049,"threshold_uncertainty_score":0.04255432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01847279921815907,"score_gpt":0.264859683959201,"score_spread":0.2463868847410419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}