{"id":"W6998547530","doi":"","title":"Analgesia, enhancement of spinal morphine antinociception, and inhibition of tolerance by ultra-low dose of the α<inf>2A</inf>-adrenoceptor selective antagonist BRL44408","year":2014,"lang":"en","type":"article","venue":"eScholarship (California Digital Library)","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Morphine; Nociception; Agonist; Antagonist; Analgesic; Norepinephrine; Tail flick test; Mechanism of action","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001216011,0.000601514,0.0004135112,0.0002344439,0.00008855724,0.000216892,0.0002969039,0.0003382749,0.003273167],"category_scores_gemma":[0.0001364551,0.0002254823,0.0002504001,0.0001428512,0.0002549804,0.0002367145,0.0001969798,0.001232722,0.0006519812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001770295,"about_ca_system_score_gemma":0.0002679062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004772316,"about_ca_topic_score_gemma":0.001321571,"domain_scores_codex":[0.9998746,0.00001704888,0.00001277417,0.00001566561,0.00003894619,0.00004093353],"domain_scores_gemma":[0.9998624,0.00001638556,0.0000525072,0.00001130695,0.00001189174,0.00004538044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003616326,0.0001321216,0.0001016739,0.00005780629,0.000007350059,0.00003410617,0.00001100457,0.00002914316,0.9970961,0.00002353215,0.00004704543,0.002098573],"study_design_scores_gemma":[0.000137683,0.008708665,0.01317122,0.00002348956,0.0000403392,0.0003860875,0.00003136291,0.0006343969,0.9753662,0.00002543203,0.001464201,0.00001093948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994888,0.001587545,0.001150958,0.0001010301,0.0000337114,0.00005090926,0.0002784628,0.0001114885,0.001797991],"genre_scores_gemma":[0.9868714,0.002545245,0.002798761,0.000167291,0.0000552004,0.0001009827,0.0009138855,0.00002671008,0.006520534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003273167,"threshold_uncertainty_score":0.01094979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00633327891521467,"score_gpt":0.2102668133448927,"score_spread":0.203933534429678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}