{"id":"W6998989435","doi":"","title":"Bioassays of Analogs of Pleurocidin-Amide Indicate that Change at <em>N</em>-Terminus is Key to Improved Efficacy","year":2011,"lang":"en","type":"article","venue":"Journal of Media Literacy Education","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institute on Drug Abuse; Office of Naval Research; Agencia Española de Cooperación Internacional para el Desarrollo; Fundação para a Ciência e a Tecnologia; Japan Society for the Promotion of Science; National Health and Medical Research Council; Basic Energy Sciences; Canadian Institutes of Health Research; University of North Carolina at Chapel Hill; U.S. Public Health Service; American Chemical Society Petroleum Research Fund; Office of Science; Université de Reims Champagne-Ardenne; Deutsche Krebshilfe; Indian Institute of Technology Bombay; Centre National de la Recherche Scientifique; National Center of Neurology and Psychiatry; Akademie Věd České Republiky; National Center for Research Resources; Fonds Québécois de la Recherche sur la Nature et les Technologies; Council for Higher Education; Conselho Nacional de Desenvolvimento Científico e Tecnológico; VINNOVA; Ministerstvo Školství, Mládeže a Tělovýchovy; Heart and Stroke Foundation of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; European Commission; Fundação de Amparo à Pesquisa do Estado de São Paulo; FP7 International Cooperation; Natural Sciences and Engineering Research Council of Canada; China Scholarship Council; Ministry of Education, Culture, Sports, Science and Technology; Deutsche Forschungsgemeinschaft; Camille and Henry Dreyfus Foundation; American Diabetes Association; Enterprise Ireland; Agencia Nacional de Promoción Científica y Tecnológica; U.S. Department of Defense; Cancer Research UK; Grantová Agentura České Republiky; Università degli Studi di Padova; Cystic Fibrosis Canada; Institute for Research in Biomedicine; Université Laval; Santa Clara University; Universitetet i Tromsø; Generalitat de Catalunya; Universidade Federal do ABC; Department of Science and Technology, Ministry of Science and Technology, India; National Institutes of Health; Florida Department of Health; National Science Foundation; Science Foundation Ireland; Ministero dell’Istruzione, dell’Università e della Ricerca; Medical Research Council; Prostate Cancer Foundation; Eli Lilly and Company; Research Corporation for Science Advancement; National Institute of Dental and Craniofacial Research; Royal Society; Fonds National de la Recherche Luxembourg; American Heart Association; Universidad de Buenos Aires; Ministerio de Ciencia e Innovación; U.S. Department of Energy","keywords":"Key (lock); Bioassay; Component (thermodynamics); Action (physics)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003192225,0.0003923274,0.000251036,0.0001611504,0.0001088795,0.0002929179,0.0002646049,0.0005039251,0.006836104],"category_scores_gemma":[0.0003240927,0.0001006257,0.0003014372,0.0001643065,0.0001673806,0.0003384353,0.0001221465,0.0009993293,0.001496941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002355669,"about_ca_system_score_gemma":0.0001468816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003625724,"about_ca_topic_score_gemma":0.000599926,"domain_scores_codex":[0.9998322,0.00003423784,0.00001542567,0.00003319082,0.00005829154,0.0000266897],"domain_scores_gemma":[0.9998028,0.000058803,0.0000330204,0.0000225049,0.00002402209,0.00005882656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003699847,0.0001074631,0.000119243,0.00009887787,0.00001587202,0.00004102955,0.00001025768,0.0002324939,0.9927047,0.0001190069,0.0003667024,0.005814407],"study_design_scores_gemma":[0.00006151434,0.003069332,0.002500775,0.00001735312,0.00001986193,0.0003331446,0.00002202086,0.000856426,0.9882443,0.00007143822,0.004794236,0.000009566116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9485339,0.007514724,0.009071037,0.0004432926,0.0005789095,0.0002871032,0.001843749,0.0003133335,0.03141391],"genre_scores_gemma":[0.9719459,0.001529554,0.007457211,0.0004304906,0.00004096009,0.00007219051,0.003623282,0.00004310273,0.01485714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006836104,"threshold_uncertainty_score":0.02286911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1177087630080273,"score_gpt":0.3950922375279525,"score_spread":0.2773834745199252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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