{"id":"W6998989435","doi":"","title":"Bioassays of Analogs of Pleurocidin-Amide Indicate that Change at <em>N</em>-Terminus is Key to Improved Efficacy","year":2011,"lang":"en","type":"article","venue":"Journal of Media Literacy Education","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institute on Drug Abuse; Office of Naval Research; Agencia Española de Cooperación Internacional para el Desarrollo; Fundação para a Ciência e a Tecnologia; Japan Society for the Promotion of Science; National Health and Medical Research Council; Basic Energy Sciences; Canadian Institutes of Health Research; University of North Carolina at Chapel Hill; U.S. Public Health Service; American Chemical Society Petroleum Research Fund; Office of Science; Université de Reims Champagne-Ardenne; Deutsche Krebshilfe; Indian Institute of Technology Bombay; Centre National de la Recherche Scientifique; National Center of Neurology and Psychiatry; Akademie Věd České Republiky; National Center for Research Resources; Fonds Québécois de la Recherche sur la Nature et les Technologies; Council for Higher Education; Conselho Nacional de Desenvolvimento Científico e Tecnológico; VINNOVA; Ministerstvo Školství, Mládeže a Tělovýchovy; Heart and Stroke Foundation of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; European Commission; Fundação de Amparo à Pesquisa do Estado de São Paulo; FP7 International Cooperation; Natural Sciences and Engineering Research Council of Canada; China Scholarship Council; Ministry of Education, Culture, Sports, Science and Technology; Deutsche Forschungsgemeinschaft; Camille and Henry Dreyfus Foundation; American Diabetes Association; Enterprise Ireland; Agencia Nacional de Promoción Científica y Tecnológica; U.S. Department of Defense; Cancer Research UK; Grantová Agentura České Republiky; Università degli Studi di Padova; Cystic Fibrosis Canada; Institute for Research in Biomedicine; Université Laval; Santa Clara University; Universitetet i Tromsø; Generalitat de Catalunya; Universidade Federal do ABC; Department of Science and Technology, Ministry of Science and Technology, India; National Institutes of Health; Florida Department of Health; National Science Foundation; Science Foundation Ireland; Ministero dell’Istruzione, dell’Università e della Ricerca; Medical Research Council; Prostate Cancer Foundation; Eli Lilly and Company; Research Corporation for Science Advancement; National Institute of Dental and Craniofacial Research; Royal Society; Fonds National de la Recherche Luxembourg; American Heart Association; Universidad de Buenos Aires; Ministerio de Ciencia e Innovación; U.S. Department of Energy","keywords":"Key (lock); Bioassay; Component (thermodynamics); Action (physics)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000798943,0.0002465243,0.0005206115,0.0005436366,0.00008660794,0.00001944218,0.0004378494,0.0002778298,0.001682162],"category_scores_gemma":[0.0006014965,0.0002110321,0.0002600925,0.0004246373,0.0001208316,0.0004448072,0.0001036068,0.0005633502,0.00004241792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000168238,"about_ca_system_score_gemma":0.0002751845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003451347,"about_ca_topic_score_gemma":0.00001602473,"domain_scores_codex":[0.9978807,0.0002076962,0.000998921,0.0002407193,0.0003365851,0.0003353595],"domain_scores_gemma":[0.9966032,0.0006308421,0.00141048,0.0002721534,0.0006154196,0.0004679433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001360511,0.002741343,0.02084405,0.0001950656,0.0003430599,0.00001907794,0.0810414,0.000001083342,0.716556,0.00009516553,0.01772258,0.1590807],"study_design_scores_gemma":[0.001845571,0.0005325276,0.1065616,0.0002333513,0.0004937948,0.0001639924,0.000755582,0.00007153598,0.7414006,0.0003109885,0.1473245,0.0003059029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938287,0.001329197,0.00002507425,0.0008978267,0.002739482,0.0003652347,0.00007937466,0.0000115862,0.0007235897],"genre_scores_gemma":[0.9949095,0.0009284373,0.001347757,0.001470046,0.0008331878,0.00003094731,0.00003555138,0.00002808566,0.0004165389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1587748,"threshold_uncertainty_score":0.9992304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1177087630080273,"score_gpt":0.3950922375279525,"score_spread":0.2773834745199252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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