{"id":"W6999535470","doi":"","title":"Designing a DNA-encoded library of aptamer-like oligomers that target an antibody drug.","year":2023,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University","keywords":"Antibody; Monoclonal antibody; Cell culture; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002258746,0.0003728762,0.0003031311,0.0003053987,0.0002198458,0.0005574003,0.000380988,0.000527955,0.00233337],"category_scores_gemma":[0.0004709256,0.0003164312,0.000343096,0.0003191662,0.0001630457,0.0003483153,0.0003385147,0.0007519897,0.001181211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003395383,"about_ca_system_score_gemma":0.0002318011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004710563,"about_ca_topic_score_gemma":0.001009122,"domain_scores_codex":[0.9997875,0.0000285613,0.00001226512,0.00005652662,0.00006600608,0.00004915705],"domain_scores_gemma":[0.9998925,0.00002395932,0.00002095592,0.000007407555,0.00001967268,0.00003554647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007963286,0.000104009,0.0001448512,0.00007463414,0.00001319747,0.00009056545,0.00005060064,0.00154323,0.9820443,0.0003325433,0.000272693,0.01524967],"study_design_scores_gemma":[0.00004752452,0.0004994773,0.000586894,0.0000124957,0.00002582016,0.0002662358,0.00003957839,0.004150536,0.9882072,0.0001329486,0.006014466,0.00001692936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8271809,0.004762846,0.1467947,0.0005298886,0.0002704044,0.00100763,0.0009392258,0.001392998,0.01712155],"genre_scores_gemma":[0.8463842,0.003292991,0.1233669,0.0007482182,0.00003419945,0.0003622341,0.001934473,0.0002204416,0.02365633],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.00233337,"threshold_uncertainty_score":0.007805884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01438158121629339,"score_gpt":0.2701289616142259,"score_spread":0.2557473803979325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}