{"id":"W6999830536","doi":"","title":"Development and application of chemical tools for the design and synthesis of bioactive molecules","year":2010,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Peptidomimetic; Drug discovery; Oligopeptidase; Exploit; Variety (cybernetics); Chemical space; Process (computing)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001071506,0.000807397,0.0005049143,0.001589846,0.0004390738,0.001498985,0.0008221039,0.000847949,0.003039407],"category_scores_gemma":[0.0008543541,0.0007912302,0.0006852611,0.001053919,0.001025375,0.001614967,0.0009291127,0.002140118,0.00235428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008415847,"about_ca_system_score_gemma":0.001011225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000332109,"about_ca_topic_score_gemma":0.0003631416,"domain_scores_codex":[0.9993445,0.00009738727,0.0000554006,0.0001066507,0.0003328471,0.00006315409],"domain_scores_gemma":[0.9997095,0.0001031263,0.00004669818,0.00005335201,0.00006171755,0.00002546524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001040641,0.0001611777,0.0003487048,0.00396083,0.00006167962,0.0005745676,0.0005780546,0.006162358,0.4726373,0.1676457,0.005274334,0.3424912],"study_design_scores_gemma":[0.00005545906,0.0004930797,0.0004657407,0.0005004742,0.00005003451,0.0009298847,0.0001233574,0.006293067,0.398583,0.02803943,0.5643857,0.0000808072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.04276158,0.2000839,0.6671811,0.002853592,0.001309974,0.0005780942,0.0009606805,0.002112635,0.08215839],"genre_scores_gemma":[0.1656848,0.2157587,0.589025,0.001162794,0.0005105129,0.001054707,0.0007817528,0.0003982821,0.02562355],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.003039407,"threshold_uncertainty_score":0.0101679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02057169076863817,"score_gpt":0.2619433640390098,"score_spread":0.2413716732703716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}