{"id":"W7000153913","doi":"","title":"Enzyme-instructed siRNA Release and Functional Self-assembly of Peptide-based Delivery System","year":2021,"lang":"en","type":"dissertation","venue":"UWSpace (University of Waterloo)","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Waterloo; Mitacs","keywords":"Endosome; Transfection; Small interfering RNA; Peptide; Endocytosis; RNA; RNA interference; Liposome; Phosphorylation; Gene delivery","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001288677,0.0002763936,0.0001364581,0.0001204374,0.0001301806,0.0002195854,0.0001788846,0.0002393904,0.0006352742],"category_scores_gemma":[0.00008976232,0.0001517539,0.0001902027,0.00008950958,0.0001421784,0.0001712875,0.0001538126,0.0003170242,0.0003485162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003581276,"about_ca_system_score_gemma":0.0003554766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009225497,"about_ca_topic_score_gemma":0.001104185,"domain_scores_codex":[0.9999226,0.00000819227,0.000008369693,0.00001955468,0.00002423059,0.00001711694],"domain_scores_gemma":[0.9999698,0.000002923796,0.000007200186,0.000002596716,0.00001015924,0.000007311578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001033205,0.00001422465,0.0000196656,0.00002156979,0.000001645041,0.00002956501,0.0000115592,0.00009728177,0.9985915,0.0001845978,0.00003083427,0.0009872534],"study_design_scores_gemma":[0.000006738843,0.00005911946,0.0003290662,0.000001923551,0.000004575655,0.00005599817,0.000003723701,0.001033072,0.9971156,0.00001927198,0.001367169,0.000003654884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.957625,0.002284467,0.03027197,0.0001741426,0.00006643472,0.0001938004,0.0001915214,0.00019082,0.009001949],"genre_scores_gemma":[0.976651,0.001384958,0.01350879,0.00008815802,0.00001096597,0.00009237648,0.0002944714,0.00003187484,0.007937477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009225497,"threshold_uncertainty_score":0.002598464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006140010028352442,"score_gpt":0.1794455569243863,"score_spread":0.1733055468960339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}