{"id":"W7000902522","doi":"","title":"Histone deacetylase inhibitors induce reactive oxygen species and DNA damage, and display enhanced activity in DNA repair deficient acute myeloid leukemia expressing leukemia associated fusion proteins","year":2014,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"McGill University","keywords":"DNA damage; DNA; DNA repair; Leukemia; Histone; Chromatin; Myeloid leukemia; Histone deacetylase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008736035,0.0001955141,0.0001845829,0.0001858279,0.00007290333,0.0001868584,0.0001099747,0.0001273278,0.0008411378],"category_scores_gemma":[0.00006144441,0.00008015149,0.0001565336,0.0001720558,0.00008337184,0.0001013829,0.00006802471,0.0002836034,0.0001649809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001721957,"about_ca_system_score_gemma":0.0001075098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000368732,"about_ca_topic_score_gemma":0.0007936924,"domain_scores_codex":[0.9999301,0.000008302023,0.000007816491,0.00001060219,0.00002714774,0.00001587984],"domain_scores_gemma":[0.9999678,0.000005813109,0.00001153412,0.000003581701,0.000003704744,0.000007535762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007308095,0.00004148023,0.0001630088,0.00001738465,0.000004210771,0.00001663397,0.000005192805,0.00008776198,0.9977749,0.00005202354,0.00003825629,0.001726161],"study_design_scores_gemma":[0.00001580393,0.0005452207,0.002423786,0.000001431168,0.000009247614,0.00008653291,0.000006402367,0.0004969165,0.9953062,0.00001976185,0.001087381,0.000001223707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959458,0.001109432,0.001471683,0.00005792503,0.00001555897,0.00002674035,0.0002299959,0.0000661447,0.001076785],"genre_scores_gemma":[0.9942151,0.001115227,0.001907307,0.00003165672,0.000006706667,0.00002756005,0.0006266148,0.000009105465,0.002060713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008411378,"threshold_uncertainty_score":0.002813876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01061406958434747,"score_gpt":0.2590196376797578,"score_spread":0.2484055680954103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}