{"id":"W7001020279","doi":"","title":"Improving aerosolization and potency of a thermally stable spray dried vaccine platform for inhalation delivery","year":2023,"lang":"en","type":"dissertation","venue":"MacSphere (McMaster University)","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; McMaster University; Ontario Centres of Excellence","keywords":"Aerosolization; Inhalation; Potency; Immunization; Aerosol; Spray drying; Microsphere","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002290479,0.0002786408,0.0002611978,0.0001777573,0.0001026376,0.00025581,0.0002107805,0.0003101483,0.0006265583],"category_scores_gemma":[0.000196515,0.0001384569,0.0003132161,0.00008554426,0.0001449558,0.0002159097,0.0001775101,0.0004921443,0.0002942361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002249374,"about_ca_system_score_gemma":0.0001945102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003479508,"about_ca_topic_score_gemma":0.0006132582,"domain_scores_codex":[0.9998404,0.00001832977,0.00001410569,0.00003702147,0.00006725937,0.00002299599],"domain_scores_gemma":[0.9999049,0.00001841701,0.00002963576,0.000008125427,0.00002675795,0.00001225335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001145824,0.000007902349,0.00002654221,0.0000241727,0.000001885343,0.00001558898,0.0000051187,0.00006883785,0.9989512,0.00001961862,0.00001240571,0.0008553078],"study_design_scores_gemma":[0.000003601687,0.0002329472,0.0003770033,0.000003982979,0.000006690832,0.00005142867,0.000006076609,0.0008605787,0.9977984,0.00000826265,0.0006478966,0.000003122695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785197,0.002674671,0.01680732,0.0000893021,0.00005700946,0.0001264317,0.0001995776,0.0001505821,0.001375306],"genre_scores_gemma":[0.9783832,0.001715319,0.01785166,0.00006071727,0.00001751099,0.00008813114,0.0002479724,0.00003526753,0.001600185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006265583,"threshold_uncertainty_score":0.002096057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01489670393062452,"score_gpt":0.2224725794829018,"score_spread":0.2075758755522773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}