{"id":"W7002319942","doi":"","title":"
\\nBiochemical and structural characterization of tau oligomers and cerebrospinal-fluid-derived tau in murine models of tauopathy
\\n","year":2020,"lang":"en","type":"dissertation","venue":"edoc (University of Basel)","topic":"Indian and Buddhist Studies","field":"Arts and Humanities","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Mach-Gaensslen Foundation of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Tau protein; Tau pathology; Tauopathy; Fragmentation (computing); Pathogenesis; Genetically modified mouse; Protein aggregation; In vivo; Biomarker","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004388858,0.0001974204,0.0005190331,0.0002143397,0.000137334,0.00001352946,0.0001206968,0.0001147615,0.0002535235],"category_scores_gemma":[0.00001136253,0.0002291654,0.00007990735,0.00006525942,0.0003980309,0.0002460353,0.00006412845,0.0001415087,9.423579e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002562044,"about_ca_system_score_gemma":0.00004770168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001678437,"about_ca_topic_score_gemma":0.002171338,"domain_scores_codex":[0.9991659,0.000029973,0.0002352114,0.0002590932,0.0001711075,0.0001387424],"domain_scores_gemma":[0.9993068,0.00002078399,0.0003498934,0.00009954719,0.0001692359,0.00005373205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"qualitative","study_design_gemma":"observational","study_design_scores_codex":[0.002834822,0.0002724659,0.008429298,0.009369908,0.0006099652,0.00006378717,0.6888379,0.00002975011,0.2670303,0.01801489,0.00064075,0.003866119],"study_design_scores_gemma":[0.008534809,0.001619459,0.5857619,0.002955903,0.001040845,0.00001018659,0.334614,0.0077478,0.05024892,0.002217954,0.002721196,0.002527002],"study_design_candidate":"qualitative","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973286,0.0002044852,0.000007353161,0.0000854677,0.0001543177,0.000178539,0.0003224629,0.000012409,0.001706383],"genre_scores_gemma":[0.9973949,0.0004442649,0.0000454136,0.00001551487,0.00005979196,4.023663e-7,0.0008327957,0.00001414445,0.001192781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5773326,"threshold_uncertainty_score":0.9345094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01177138721145972,"score_gpt":0.1834034478254397,"score_spread":0.17163206061398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}