{"id":"W7002319942","doi":"","title":"
\\nBiochemical and structural characterization of tau oligomers and cerebrospinal-fluid-derived tau in murine models of tauopathy
\\n","year":2020,"lang":"en","type":"dissertation","venue":"edoc (University of Basel)","topic":"Indian and Buddhist Studies","field":"Arts and Humanities","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Mach-Gaensslen Foundation of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Tau protein; Tau pathology; Tauopathy; Fragmentation (computing); Pathogenesis; Genetically modified mouse; Protein aggregation; In vivo; Biomarker","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000548144,0.0008465967,0.0004042433,0.001108271,0.0004453147,0.0004607039,0.0004709945,0.0009008594,0.00288269],"category_scores_gemma":[0.0001921152,0.0003328127,0.0005782818,0.0002920252,0.0004789399,0.0004842281,0.0003554627,0.001438343,0.001810175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006249847,"about_ca_system_score_gemma":0.0003643967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001698748,"about_ca_topic_score_gemma":0.002444591,"domain_scores_codex":[0.9995467,0.00004412526,0.00006168972,0.0001044579,0.0001450254,0.00009790046],"domain_scores_gemma":[0.9996893,0.00001942927,0.00007383755,0.00004308812,0.0001026763,0.00007158935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001726874,0.0001295549,0.000207775,0.0001082256,0.00001219877,0.0001560888,0.00004705642,0.0001008793,0.9960097,0.0003784706,0.0004338746,0.002243573],"study_design_scores_gemma":[0.00006763497,0.001080647,0.0060577,0.00008266454,0.00006259837,0.001109251,0.00009564019,0.001906403,0.9622776,0.0004637323,0.02675877,0.00003719077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8701925,0.01722351,0.05988895,0.00277881,0.001565646,0.001393154,0.02099941,0.001356736,0.0246013],"genre_scores_gemma":[0.8383393,0.01551429,0.06844779,0.001495734,0.0002388306,0.002416957,0.02106155,0.0004952005,0.05199024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00288269,"threshold_uncertainty_score":0.009643555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01177138721145972,"score_gpt":0.1834034478254397,"score_spread":0.17163206061398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}