{"id":"W7006141880","doi":"","title":"Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms.","year":2017,"lang":"en","type":"article","venue":"The Medicine Forum","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Importin; Nucleoprotein; Nuclear localization sequence; Avidity; Virus; Nuclear transport; NLS; Viral replication","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002059114,0.0003006717,0.0002271538,0.0001009392,0.0001979359,0.0004007293,0.0002317436,0.0003887131,0.001207844],"category_scores_gemma":[0.0002004824,0.0001618535,0.0002428755,0.00007049875,0.0002725496,0.0002693104,0.0003588642,0.0003133779,0.0005200754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003925478,"about_ca_system_score_gemma":0.0001910134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004121482,"about_ca_topic_score_gemma":0.0004922387,"domain_scores_codex":[0.9997621,0.00003922322,0.00001160638,0.00006563268,0.00007129606,0.00005021843],"domain_scores_gemma":[0.9998268,0.00003423557,0.00004395884,0.00001471979,0.00002350834,0.00005677787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005904834,0.000006468436,0.0005537329,0.000009875395,0.000003250732,0.00005275547,0.000006760496,0.00004615504,0.9987524,0.00009644834,0.00002215741,0.0003909883],"study_design_scores_gemma":[0.00002514099,0.0002010899,0.01287091,0.000004911449,0.00001481577,0.000941828,0.00004510665,0.0039524,0.9797406,0.0001798452,0.002010896,0.00001260482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950475,0.0005928332,0.002922115,0.00006318394,0.00001154835,0.00000694189,0.00005436147,0.00004559848,0.00125603],"genre_scores_gemma":[0.9982474,0.00007264834,0.001027894,0.00002317737,0.000002875987,0.000003687625,0.0001136453,0.000007445968,0.0005012578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001207844,"threshold_uncertainty_score":0.004040718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01886827555304035,"score_gpt":0.3144417737099265,"score_spread":0.2955734981568862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}