{"id":"W7006524923","doi":"","title":"Understanding the genetic complexity of puberty timing across the allele frequency spectrum","year":2024,"lang":"en","type":"article","venue":"UWA Profiles and Research Repository (University of Western Australia)","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Population and Public Health","funders":"","keywords":"Allele frequency; Allele; Genetic variation; Frequency spectrum; Population; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009131673,0.0001129019,0.0002495086,0.00008337032,0.0005895019,0.000066361,0.0002818346,0.00007968675,0.00003893236],"category_scores_gemma":[0.00003001123,0.00007324006,0.0001166954,0.0002378087,0.002245809,0.0001347438,0.0002839837,0.0004856792,0.00000702568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001280587,"about_ca_system_score_gemma":0.0001102697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00160174,"about_ca_topic_score_gemma":0.00009769783,"domain_scores_codex":[0.9983497,0.0002327851,0.0001715883,0.0003430078,0.0005583902,0.0003445184],"domain_scores_gemma":[0.9990528,0.000206232,0.00007527287,0.0004414957,0.0001367137,0.0000874977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009938932,0.0004165269,0.3826364,0.003966505,0.002206132,0.001873701,0.04536122,0.00004619678,0.5282372,0.02539234,0.004989536,0.003880308],"study_design_scores_gemma":[0.0008881035,0.0006605171,0.9317055,0.0004990756,0.000215202,0.0006619858,0.03884634,0.0009866294,0.01786757,0.006399982,0.001067564,0.0002015472],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873593,0.001119451,0.0006527419,0.00938989,0.0000915055,0.0005931248,0.0000157152,0.00002619611,0.0007520678],"genre_scores_gemma":[0.9922848,0.0001072457,0.0002894845,0.000004413454,0.0001289286,0.00000108799,0.000003093196,0.0000116343,0.00716929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.549069,"threshold_uncertainty_score":0.8274776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2837296335713044,"score_gpt":0.3645285015735121,"score_spread":0.08079886800220776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}