{"id":"W7008032366","doi":"","title":"Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate and 5-fluorouracil in mice","year":2008,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Library and Archives Canada","funders":"Canadian Institutes of Health Research; Hacettepe Üniversitesi; McGill University","keywords":"Methotrexate; Methylenetetrahydrofolate reductase; Enzyme; DNA; Reductase; Dihydrofolate reductase; Nucleotide; RNA; Antimetabolite; DNA synthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004468552,0.0005596944,0.0004623677,0.00181588,0.0003252535,0.0007277802,0.0005952016,0.001235711,0.004506711],"category_scores_gemma":[0.0002730255,0.0006709772,0.0007561291,0.0004741724,0.0006403744,0.000445291,0.0003122625,0.001574748,0.002337553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009537939,"about_ca_system_score_gemma":0.0003579229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002215114,"about_ca_topic_score_gemma":0.002755925,"domain_scores_codex":[0.9994984,0.00008945705,0.00004317695,0.0001347383,0.0001045802,0.0001296752],"domain_scores_gemma":[0.9995265,0.00006622279,0.0001887999,0.00004994999,0.00003693296,0.0001315532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009504552,0.0003216963,0.0008006445,0.0000383809,0.00002625014,0.0001841366,0.00006714341,0.0001335607,0.9938886,0.0003170767,0.0002750838,0.002996876],"study_design_scores_gemma":[0.0005667908,0.003991148,0.03182085,0.0001326469,0.0002382813,0.001470866,0.0003084098,0.00153639,0.9449917,0.0005891368,0.01428592,0.00006802833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804839,0.003540655,0.003386455,0.001028909,0.0001589435,0.0001148194,0.004352769,0.0004072932,0.006526156],"genre_scores_gemma":[0.9486123,0.003920186,0.003906224,0.0007067989,0.00005865135,0.0002040685,0.003056597,0.0002509411,0.03928428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004506711,"threshold_uncertainty_score":0.01507646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03265355396860554,"score_gpt":0.3116431143731536,"score_spread":0.2789895604045481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}