{"id":"W7008565290","doi":"","title":"A closer look into Parkinson’s Disease GWAS genes: targeted next-generation sequencing approach","year":2020,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre","funders":"Common Fund; National Institute of Neurological Disorders and Stroke; National Cancer Institute; NIH Office of the Director; National Human Genome Research Institute; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; National Institute of Mental Health; Canadian Glycomics Network; Fonds de Recherche du Québec - Santé; National Institutes of Health; Canada First Research Excellence Fund; Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; Parkinson Canada; McGill University; Brookdale Foundation","keywords":"Disease; Genome-wide association study; Life expectancy; Population; Genetic association; Depression (economics); Association (psychology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006092221,0.0007373629,0.001849661,0.002243518,0.0008275621,0.00238408,0.0009325058,0.002327841,0.006550802],"category_scores_gemma":[0.01207946,0.0004722348,0.002300611,0.002642781,0.0003937662,0.001249285,0.0008714159,0.003910057,0.001494943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007065907,"about_ca_system_score_gemma":0.001643895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005584081,"about_ca_topic_score_gemma":0.0138677,"domain_scores_codex":[0.997566,0.001120598,0.00021411,0.0005335424,0.0004240186,0.0001418048],"domain_scores_gemma":[0.9937364,0.004267439,0.0003264164,0.0004595024,0.0008629774,0.0003473366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001386773,0.0003301864,0.1574903,0.00730387,0.01182008,0.006018574,0.002167023,0.005366761,0.03609385,0.02582267,0.1870465,0.5591534],"study_design_scores_gemma":[0.0006482231,0.001092887,0.2040516,0.006146006,0.008876961,0.01065653,0.001440301,0.01367432,0.005539502,0.08966266,0.6578209,0.0003900543],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1393828,0.288478,0.3375829,0.1432064,0.0131607,0.0006923676,0.05033377,0.004405672,0.02275738],"genre_scores_gemma":[0.3807539,0.1536133,0.2818669,0.1255386,0.006592648,0.001364545,0.03481812,0.002118089,0.01333385],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006550802,"threshold_uncertainty_score":0.03221911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04722831412526502,"score_gpt":0.2604398661330125,"score_spread":0.2132115520077474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}