{"id":"W7008752584","doi":"","title":"CYP2D in the Brain Alters Response to Drugs and Neurotoxins","year":2021,"lang":"","type":"dissertation","venue":"TSpace","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Canada Research Chairs; Canadian Institutes of Health Research; Centre for Addiction and Mental Health Foundation","keywords":"Genetically modified mouse; Transgene; In vivo; Methamphetamine; Drug; Hypothermia; Human brain","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001041362,0.0004820171,0.0003607632,0.0002424466,0.0001676838,0.0002554184,0.0001532384,0.0003345777,0.001603439],"category_scores_gemma":[0.00009212118,0.0001786158,0.0003265727,0.0001634421,0.0002990938,0.0001874069,0.0001118623,0.0008844024,0.000271097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003268876,"about_ca_system_score_gemma":0.0003032381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008217413,"about_ca_topic_score_gemma":0.001908743,"domain_scores_codex":[0.9998857,0.00001303326,0.000008683771,0.00003106796,0.00003114755,0.00003042765],"domain_scores_gemma":[0.9999347,0.000006496229,0.00002018101,0.000008224699,0.00001048489,0.00001995384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004572721,0.00008330121,0.0005071296,0.00003201178,0.00001400033,0.00008166135,0.00001550035,0.00003445784,0.996795,0.00006938855,0.00006918806,0.00184111],"study_design_scores_gemma":[0.00002570001,0.001281647,0.01163886,0.000004976655,0.00003776482,0.0002017781,0.00003049307,0.0003502186,0.9850375,0.00004432541,0.001341788,0.000004887515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957541,0.001298839,0.001084312,0.0001483919,0.00005357298,0.00002776238,0.0003604516,0.00008040707,0.001192293],"genre_scores_gemma":[0.9907302,0.00181708,0.00132681,0.00008289014,0.00002224851,0.00005908003,0.0006201817,0.00001924931,0.00532234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001603439,"threshold_uncertainty_score":0.005364001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07343712034392316,"score_gpt":0.4798721167220362,"score_spread":0.406434996378113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}