{"id":"W7008853515","doi":"","title":"Crystal structure of cGMP-dependent protein kinase IÎ² cyclic nucleotide-binding-B domain : Rp-cGMPS complex reveals an apo-like, inactive conformation","year":2017,"lang":"en","type":"article","venue":"eScholarship (California Digital Library)","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Basic Energy Sciences; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Office of Science; National Institutes of Health; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; U.S. Department of Energy","keywords":"Protein subunit; Protein kinase A; Crystal structure; cGMP-dependent protein kinase; Protein structure; Domain (mathematical analysis); Enzyme; Kinase; Protein domain","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001396623,0.0003281274,0.0002985547,0.0001041322,0.0004158789,0.0006516777,0.0005072223,0.0002903057,0.0002024567],"category_scores_gemma":[0.0001438512,0.0003002183,0.0001500581,0.00007972008,0.0002223903,0.0006106124,0.0003122097,0.0002484713,0.0000614924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003319557,"about_ca_system_score_gemma":0.00008716949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007464462,"about_ca_topic_score_gemma":0.000009203477,"domain_scores_codex":[0.9982442,0.0001094026,0.000515142,0.0004594197,0.0003324325,0.0003393581],"domain_scores_gemma":[0.9982216,0.00001205227,0.0006119536,0.0008045762,0.00009682772,0.0002530215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000655369,0.0001638894,0.02447692,0.00008770442,0.00007849348,0.00000741758,0.00005008572,0.00001839197,0.9712201,0.0006067313,0.0006862956,0.001948628],"study_design_scores_gemma":[0.002667086,0.0007336321,0.08212982,0.0001693253,0.00003471434,0.00003946875,0.0002711282,0.00008393617,0.8535996,0.007402946,0.05198963,0.0008787223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992002,0.00003871386,0.0004694359,0.0001573403,0.0001497551,0.0006123643,0.003607254,0.00005851559,0.002904623],"genre_scores_gemma":[0.9930677,0.000006579974,0.0005807209,0.000178033,0.0001536304,0.0000156275,0.005213326,0.00005713837,0.0007272494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1176205,"threshold_uncertainty_score":0.999945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01300641035626724,"score_gpt":0.2317785827149424,"score_spread":0.2187721723586751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}