{"id":"W7008900272","doi":"","title":"Development of a Lipid-encapsulated TGFβRI-siRNA Drug for Liver Fibrosis Induced by <i>Schistosoma mansoni</i>","year":2024,"lang":"en","type":"article","venue":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","topic":"Liver physiology and pathology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Advanced Micro Devices (Canada)","funders":"","keywords":"Drug; Fibrosis; Liver fibrosis; Liver disease; Drug development","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008421845,0.0006613954,0.001757342,0.0008211512,0.0004434844,0.00001219265,0.001428631,0.001458554,0.00153592],"category_scores_gemma":[0.0002078563,0.0007723238,0.001004141,0.001295546,0.001748182,0.0003823016,0.001008507,0.001104244,0.0001546354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006191608,"about_ca_system_score_gemma":0.0008979141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001170828,"about_ca_topic_score_gemma":0.0003812051,"domain_scores_codex":[0.9958816,0.0002845,0.0008895899,0.001309864,0.0007849954,0.000849502],"domain_scores_gemma":[0.9963678,0.0008940938,0.0005835261,0.001035337,0.0005972365,0.000521982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003926413,0.001333649,0.0002762432,0.001182957,0.0007011333,0.0004634161,0.0008818103,0.000005285149,0.9463017,0.004077225,0.03739232,0.003457836],"study_design_scores_gemma":[0.02489982,0.008214815,0.1190276,0.007056411,0.007293188,0.001027491,0.002523887,0.002142508,0.1492029,0.001887235,0.6717111,0.005013047],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767749,0.001568228,0.008610504,0.00109266,0.0002921069,0.001816862,0.0004104914,0.0004644915,0.008969769],"genre_scores_gemma":[0.9541019,0.0007016381,0.03918623,0.00007785876,0.00005775,0.000001710334,0.0001743975,0.00006492766,0.005633625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7970988,"threshold_uncertainty_score":0.9998378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01641725753978802,"score_gpt":0.2236981690756056,"score_spread":0.2072809115358175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}