{"id":"W7009089185","doi":"","title":"Development of novel therapeutic agents designed to enhance insulin secretion through activation of the trace amine-associated receptor 1 (TAAR1)","year":2025,"lang":"en","type":"other","venue":"Nottingham ePrints (University of Nottingham)","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Trent University; Nottingham Trent University","keywords":"Insulin; Agonist; Diabetes mellitus; Receptor; Type 2 Diabetes Mellitus; Insulin receptor; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001738174,0.0004209513,0.0004247937,0.0002543984,0.0001399911,0.0002922199,0.0004239945,0.0002752426,0.002169253],"category_scores_gemma":[0.0001203886,0.0001552989,0.0004218199,0.0001412113,0.0001569216,0.000246978,0.0001882774,0.0008669511,0.0006087358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001979613,"about_ca_system_score_gemma":0.0002591387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004037503,"about_ca_topic_score_gemma":0.001135471,"domain_scores_codex":[0.9999477,0.000008333256,0.00000337879,0.00001199584,0.00001340161,0.00001536499],"domain_scores_gemma":[0.9999689,0.000004311462,0.000009921959,0.00000260057,0.000004953195,0.000009324961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007971954,0.0008306748,0.0004449128,0.001151943,0.0001163176,0.0004810973,0.00009407839,0.003656006,0.9091907,0.002342109,0.002488606,0.07840642],"study_design_scores_gemma":[0.001527209,0.02171374,0.004329016,0.0002507965,0.00045063,0.001940979,0.0001223664,0.007836401,0.8487806,0.0007279426,0.1122292,0.00009097213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8767833,0.07272343,0.01973637,0.001489174,0.0006349194,0.0008635463,0.002121838,0.0007040063,0.02494344],"genre_scores_gemma":[0.9272271,0.04468392,0.01600362,0.0006686703,0.00007933663,0.0003154474,0.001752057,0.00003590139,0.009233937],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002169253,"threshold_uncertainty_score":0.007256866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03458355106969407,"score_gpt":0.2723560659068986,"score_spread":0.2377725148372046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}