{"id":"W7009094202","doi":"","title":"Development and characterization of glial cell models of Autosomal Recessive Spastic Ataxia of Charle-voix-Saguenay","year":2025,"lang":"en","type":"dissertation","venue":"Universidade Nova de Lisboa's Repository (Universidade Nova de Lisboa)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Ataxia; Neurofilament; Cytoskeleton; Organelle; Cell; Mitochondrion; Intermediate filament; Cerebellum","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001822323,0.0008920276,0.001254958,0.001760298,0.0003499738,0.0000890499,0.001242543,0.000823204,0.000108033],"category_scores_gemma":[0.0002016787,0.001126703,0.0003685507,0.001502353,0.0004160554,0.0007670271,0.0003451586,0.0007123871,0.000004011724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004750524,"about_ca_system_score_gemma":0.002359194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003186034,"about_ca_topic_score_gemma":0.0001015186,"domain_scores_codex":[0.9950368,0.0004866011,0.001163763,0.00145421,0.001078577,0.0007800684],"domain_scores_gemma":[0.9952272,0.0003474307,0.002352852,0.0008470992,0.0008516414,0.0003737605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001055565,0.0004493207,0.0006839733,0.001715515,0.0001324951,0.0002148216,0.006488792,0.0008100033,0.9864281,0.001253238,0.0001876119,0.000580542],"study_design_scores_gemma":[0.001756113,0.0002476322,0.01127533,0.0009481449,0.0005895148,0.00003076864,0.003206394,0.001943387,0.9787278,0.00005884971,0.0004237826,0.0007923029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852118,0.0001288022,0.001113373,0.00007373715,0.001074308,0.0009161794,0.0005560823,0.00009168462,0.010834],"genre_scores_gemma":[0.9795299,0.0001287597,0.00190864,0.00006932578,0.0001208152,0.000009514423,0.0005241426,0.0001098453,0.01759912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01059136,"threshold_uncertainty_score":0.9991183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0228620053474028,"score_gpt":0.2348858575449812,"score_spread":0.2120238521975784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}