{"id":"W7009561271","doi":"","title":"Enhancer Binding Site Architecture Regulates Cell-specific Notch Signal Strength and Transcription","year":2020,"lang":"en","type":"article","venue":"OhioLink ETD Center (Ohio Library and Information Network)","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"York University; National Institutes of Health; National Science Foundation","keywords":"Enhancer; Transcription (linguistics); Transcription factor; Binding site; Notch signaling pathway; Gene expression; DNA-binding protein; Plasma protein binding","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002167903,0.0001872631,0.0002928645,0.0004228067,0.0002897895,0.0007451071,0.0004044302,0.0003907413,0.004094701],"category_scores_gemma":[0.0003072924,0.0005170733,0.0002499545,0.0001767135,0.0003279324,0.0003359051,0.0005933659,0.000705845,0.001502412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004028991,"about_ca_system_score_gemma":0.0002325254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006432297,"about_ca_topic_score_gemma":0.002490907,"domain_scores_codex":[0.999749,0.00003122622,0.00001516648,0.00007549494,0.00006080275,0.00006830261],"domain_scores_gemma":[0.9997073,0.00008527014,0.00004833018,0.00002953675,0.00004430009,0.00008510976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000110138,0.0000223864,0.0006719923,0.000008434366,0.000004150612,0.00001691718,0.00001509814,0.00009111704,0.9974456,0.0003952847,0.00003912125,0.001179752],"study_design_scores_gemma":[0.00006398174,0.000184574,0.06213401,0.00001890139,0.00004110932,0.0004080235,0.0001198722,0.00752663,0.9252591,0.0008096875,0.003406223,0.00002790827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924849,0.0004587645,0.003512115,0.00005457039,0.00002284943,0.000008055998,0.0001792567,0.0001201092,0.003159497],"genre_scores_gemma":[0.9959962,0.0001231025,0.00125637,0.00005508307,0.000007009094,0.000007921163,0.0003474083,0.00008201579,0.002124873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004094701,"threshold_uncertainty_score":0.0136981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00555653006750432,"score_gpt":0.1776506187037425,"score_spread":0.1720940886362382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}