{"id":"W7011398674","doi":"","title":"Mechanisms of rapamycin toxicity in pancreatic beta cells","year":2011,"lang":"en","type":"other","venue":"OpenGrey (Institut de l'Information Scientifique et Technique)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"mTORC2; mTORC1; PI3K/AKT/mTOR pathway; Islet; Beta cell; Toxicity; Protein kinase B; Sirolimus; In vivo","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006870669,0.0007661745,0.0006305468,0.0008234163,0.0003726484,0.001124324,0.0007193492,0.000879496,0.001000299],"category_scores_gemma":[0.0002676685,0.0003027929,0.0007850343,0.0003153536,0.0007403532,0.0006361906,0.0006197043,0.0009935318,0.000453946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006617801,"about_ca_system_score_gemma":0.0003207068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001814292,"about_ca_topic_score_gemma":0.0001632077,"domain_scores_codex":[0.9995259,0.0001195239,0.00004130785,0.00007238652,0.0001589692,0.00008192008],"domain_scores_gemma":[0.9997261,0.00005610671,0.0001152237,0.00002602917,0.00004409094,0.0000324093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009429598,0.0003617964,0.004150591,0.002501156,0.000259138,0.005145458,0.0005513944,0.002703078,0.8695388,0.02018526,0.003215882,0.09044445],"study_design_scores_gemma":[0.0001296182,0.004148651,0.02332578,0.0003743434,0.0003156174,0.01702252,0.0003467497,0.003429211,0.8735716,0.01172755,0.0655408,0.00006743751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6007342,0.3458208,0.02816358,0.003522294,0.0008186084,0.0002983802,0.0005167354,0.0008155842,0.01930987],"genre_scores_gemma":[0.8765203,0.1095784,0.0046047,0.001285847,0.0005081599,0.0002334569,0.0003620994,0.00005847922,0.006848529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001124324,"threshold_uncertainty_score":0.004801512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02077282748260872,"score_gpt":0.2595562007897668,"score_spread":0.2387833733071581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}