{"id":"W7015891347","doi":"","title":"1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD): An effective catalyst for amide formation by lactone aminolysis.","year":2023,"lang":"en","type":"article","venue":"eScholarship@McGill (McGill)","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; McGill University","keywords":"Catalysis; Amide; Lactone; Yield (engineering); Epoxide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000230536,0.0003286118,0.0001762134,0.0003579246,0.0001841538,0.000305799,0.0002514573,0.0002411215,0.001127916],"category_scores_gemma":[0.000216465,0.0001612466,0.00007804276,0.0002162525,0.0002204468,0.0002512136,0.0002874789,0.0003761146,0.000836706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003558804,"about_ca_system_score_gemma":0.0002955392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006653648,"about_ca_topic_score_gemma":0.001681368,"domain_scores_codex":[0.9997891,0.0000394684,0.00001336159,0.00005518421,0.00006952129,0.00003346868],"domain_scores_gemma":[0.9999417,0.00001058185,0.00001739691,0.000006213501,0.00001154718,0.00001257107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006116658,0.00002763443,0.0001376112,0.0001094482,0.000004788511,0.00006951981,0.00001989187,0.0002152294,0.9898661,0.0004791013,0.0002369552,0.00877252],"study_design_scores_gemma":[0.000006580773,0.0001330933,0.0004329925,0.000006228162,0.00000512802,0.0002155076,0.000007839846,0.0007229089,0.9903481,0.0000577969,0.008055465,0.000008377529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8600839,0.01948553,0.08498333,0.0004370717,0.0002882111,0.0003466418,0.001365881,0.0009563342,0.03205318],"genre_scores_gemma":[0.9481798,0.0045948,0.034647,0.000123295,0.00001937795,0.00009658578,0.0009325633,0.00009787259,0.01130874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001127916,"threshold_uncertainty_score":0.003773272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062114814725512,"score_gpt":0.2424115997168905,"score_spread":0.2317904515696354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}