{"id":"W7017967927","doi":"","title":"Characterization of novel anti-EGFR single domain antibodies and their application in active targeting of superparamagnetic iron oxide nanoparticles to glioblastoma","year":2012,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Glioblastoma; Mutant; Epidermal growth factor receptor; Magnetic resonance imaging; Iron oxide nanoparticles; Mutation; Radiation therapy; Exon; Protein kinase domain; Single-domain antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002160897,0.0002625395,0.0001598165,0.0001675848,0.00007780549,0.0001713352,0.0001834105,0.0003136075,0.0003486839],"category_scores_gemma":[0.0002492922,0.0001152161,0.0001820325,0.0001059355,0.00011175,0.0001312509,0.0001054295,0.0002067071,0.0001590863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001989829,"about_ca_system_score_gemma":0.0001100523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005566027,"about_ca_topic_score_gemma":0.0006808463,"domain_scores_codex":[0.9999186,0.0000140127,0.000007142261,0.00001457736,0.00002763789,0.00001798591],"domain_scores_gemma":[0.9999182,0.0000161357,0.0000208175,0.00000495098,0.00002615816,0.00001369887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003020967,0.00002281875,0.0000499486,0.0000352864,0.00000281224,0.00002551821,0.00001322435,0.000169905,0.9985642,0.00004736102,0.00001798534,0.001020672],"study_design_scores_gemma":[0.0000168907,0.0006144302,0.001879333,0.000009061053,0.00001991185,0.0001298771,0.00001496637,0.002579021,0.9925619,0.00004381344,0.002124098,0.000006747893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988446,0.001657464,0.008075253,0.00006891756,0.00002525663,0.0001256125,0.0001022608,0.0000339321,0.001465352],"genre_scores_gemma":[0.9926941,0.0008391226,0.004947003,0.00006972667,0.000007167976,0.00008970732,0.0002171512,0.00001633441,0.001119598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005566027,"threshold_uncertainty_score":0.001443803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009812900338821907,"score_gpt":0.2198047762169954,"score_spread":0.2099918758781735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}