{"id":"W7020031766","doi":"","title":"Investigating the role of Brain Derived Neurotrophic Factor content and signalling on Amyloid Precursor Protein processing","year":2023,"lang":"en","type":"other","venue":"Brock University Digital Repository (Brock University)","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Universities Space Research Association; Alzheimer's Society","keywords":"Brain-derived neurotrophic factor; Neurotrophic factors; Amyloid precursor protein; Neurotrophin; Cognition; Pathological; Cognitive decline; Epigenetics; Mediator","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001415284,0.0002621748,0.0002848569,0.0001465402,0.0001620097,0.0005010343,0.0001858015,0.0004350114,0.0008568063],"category_scores_gemma":[0.0001338803,0.0001202854,0.0002676719,0.000146563,0.0002434345,0.000361868,0.0001247879,0.0005620511,0.0002301852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003475195,"about_ca_system_score_gemma":0.0003114761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009104637,"about_ca_topic_score_gemma":0.001562224,"domain_scores_codex":[0.9999212,0.000009406238,0.000005308887,0.00002269444,0.00001984249,0.00002151775],"domain_scores_gemma":[0.9999262,0.00001344895,0.00002289981,0.000003633037,0.00001485627,0.00001890654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00115608,0.0001542575,0.001995708,0.0002953383,0.00003275028,0.0001386862,0.00007789492,0.00007862522,0.9828445,0.0002300959,0.00008530146,0.01291078],"study_design_scores_gemma":[0.0001396,0.005777009,0.1160089,0.0002330067,0.000250072,0.0005878746,0.0005035746,0.001055062,0.8633246,0.001389445,0.01069718,0.00003364042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818875,0.01471043,0.001325448,0.0003511662,0.00005625131,0.00002538048,0.0001659409,0.00001472547,0.001463241],"genre_scores_gemma":[0.9764093,0.01764223,0.00238659,0.0001963525,0.00003353076,0.00004922933,0.0001626288,0.000008053668,0.003112196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009104637,"threshold_uncertainty_score":0.002866328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173422170735594,"score_gpt":0.1912357695428475,"score_spread":0.1695015478354916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}