{"id":"W7020046286","doi":"","title":"Interleukin-1 receptor modulators: drawing links between structures, biased signaling, and «in vivo» efficacy in models of preterm birth and retinopathy of prematurity","year":2019,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Retinopathy of Prematurity Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Phosphorylation; In vivo; Receptor; Retinopathy of prematurity; In vitro; Allosteric regulation; Signal transduction; p38 mitogen-activated protein kinases; Blot","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004114996,0.000404173,0.0002426383,0.0002350007,0.0001240689,0.0002972072,0.0002976796,0.0003497577,0.0013526],"category_scores_gemma":[0.0001821834,0.0001768839,0.0001896436,0.0001087788,0.0002349624,0.0002828446,0.0001210806,0.0009502071,0.0002298602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002630988,"about_ca_system_score_gemma":0.0001808537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002210856,"about_ca_topic_score_gemma":0.0005073879,"domain_scores_codex":[0.9998561,0.00004337073,0.00001038676,0.00002111101,0.00002991149,0.00003909395],"domain_scores_gemma":[0.9998769,0.00002988702,0.00004256618,0.00001068986,0.00001141126,0.00002856554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006234976,0.0003504334,0.0001176548,0.0001118486,0.000007980841,0.00003712245,0.00002085469,0.0002003422,0.9931349,0.0002316607,0.0001156801,0.005048214],"study_design_scores_gemma":[0.000153675,0.007355213,0.001201927,0.00002322514,0.00003703411,0.0001703431,0.00002717687,0.0006890358,0.9877008,0.00009111994,0.00254339,0.000007080268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884177,0.005074987,0.002980323,0.0004768288,0.00007185728,0.00009257965,0.0002606901,0.0001048424,0.002520254],"genre_scores_gemma":[0.9874371,0.004612767,0.004859987,0.0001850029,0.00002940222,0.0001148174,0.0002583432,0.00001676256,0.002485781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0013526,"threshold_uncertainty_score":0.004524946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02065014057158616,"score_gpt":0.2606719091620458,"score_spread":0.2400217685904596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}