{"id":"W7021012115","doi":"","title":"
\\nINVESTIGATION OF HOW ENDOPLASMIC RETICULUM STRESS CAUSES INSULIN RESISTANCE AND NEUROINFLAMMATION
\\n
\\n","year":2015,"lang":"en","type":"dissertation","venue":"Durham e-Theses (Durham University)","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Toronto; Durham University; Diabetes UK","keywords":"Unfolded protein response; Endoplasmic reticulum; Insulin resistance; Signal transduction; Insulin; PI3K/AKT/mTOR pathway; Receptor; Insulin receptor; Secretory pathway","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001483464,0.0006251649,0.000617844,0.0004281319,0.0002201228,0.0001065768,0.0005105428,0.0006036208,0.00003292422],"category_scores_gemma":[0.0006605656,0.0006941129,0.000231183,0.0004042203,0.000376907,0.00005739796,0.0001689705,0.0003204911,0.000008021792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006030623,"about_ca_system_score_gemma":0.0005646725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002373009,"about_ca_topic_score_gemma":0.006430862,"domain_scores_codex":[0.997328,0.0002468269,0.0004497523,0.0009825447,0.0005375475,0.0004553653],"domain_scores_gemma":[0.9972706,0.00008066225,0.0007841805,0.0007684666,0.0006819827,0.0004140585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01578055,0.002436301,0.1185387,0.01567947,0.003596827,0.002237167,0.008728361,0.003298602,0.7628415,0.01159607,0.04857961,0.006686877],"study_design_scores_gemma":[0.008023351,0.001146028,0.05657228,0.002387471,0.001670898,0.00006353064,0.01585337,0.0003648615,0.81149,0.001602508,0.09722059,0.003605081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802634,0.001894805,0.00002467518,0.0001764737,0.0003718271,0.0005563694,0.0006474669,0.0000552219,0.01600972],"genre_scores_gemma":[0.9589119,0.003173514,0.0001466961,0.00003096604,0.0001989446,0.00001026378,0.003928437,0.00008636715,0.03351292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06196644,"threshold_uncertainty_score":0.999551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008683864752016102,"score_gpt":0.2106095770732315,"score_spread":0.2019257123212154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}