{"id":"W7021012115","doi":"","title":"
\\nINVESTIGATION OF HOW ENDOPLASMIC RETICULUM STRESS CAUSES INSULIN RESISTANCE AND NEUROINFLAMMATION
\\n
\\n","year":2015,"lang":"en","type":"dissertation","venue":"Durham e-Theses (Durham University)","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Toronto; Durham University; Diabetes UK","keywords":"Unfolded protein response; Endoplasmic reticulum; Insulin resistance; Signal transduction; Insulin; PI3K/AKT/mTOR pathway; Receptor; Insulin receptor; Secretory pathway","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003138363,0.000202281,0.0002903595,0.0002955297,0.0003910297,0.0007735596,0.0004262646,0.0005365197,0.007735008],"category_scores_gemma":[0.0002272879,0.0001105463,0.0003264772,0.0001977866,0.0007492194,0.0005415531,0.0005574822,0.0009088503,0.001672143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007037578,"about_ca_system_score_gemma":0.0008097875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001011863,"about_ca_topic_score_gemma":0.002251058,"domain_scores_codex":[0.9998009,0.0000341191,0.0000188071,0.00004555459,0.00006332752,0.0000373934],"domain_scores_gemma":[0.9998066,0.00002449208,0.00004095824,0.00002395927,0.00007395242,0.00003004673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001253964,0.0003369438,0.007345919,0.002686058,0.0001851566,0.002531467,0.0004014049,0.0007760719,0.5625283,0.02721116,0.08121907,0.3135245],"study_design_scores_gemma":[0.00005978206,0.0005428095,0.0255529,0.0009245805,0.0001510421,0.002031578,0.0008584673,0.001577014,0.1775241,0.01037182,0.7803435,0.00006253311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.3546328,0.2928352,0.0436189,0.1008637,0.02260596,0.0003605843,0.002904176,0.0006928322,0.1814858],"genre_scores_gemma":[0.5007415,0.2267001,0.02029561,0.01755099,0.003192215,0.0004129061,0.002085071,0.0001968185,0.2288248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007735008,"threshold_uncertainty_score":0.02587622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008683864752016102,"score_gpt":0.2106095770732315,"score_spread":0.2019257123212154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}