{"id":"W7024173078","doi":"","title":"A putative role for PCSK9 in synaptic remodelling and plasticity in response to brain injury: implications for Alzheimer's disease","year":2011,"lang":"en","type":"other","venue":"Library and Archives Canada (Government of Canada)","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PCSK9; Hippocampal formation; Downregulation and upregulation; Regulator; LDL receptor; Neuroplasticity; Hippocampus; Gene expression; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001683634,0.0005104591,0.0005600994,0.0004184431,0.0003380875,0.0006071798,0.0004710473,0.0006553509,0.001474478],"category_scores_gemma":[0.000219043,0.0001138635,0.0004039331,0.000291856,0.00064201,0.0004158466,0.0003947263,0.0007070053,0.0003444814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005148234,"about_ca_system_score_gemma":0.0003681802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008721307,"about_ca_topic_score_gemma":0.001167924,"domain_scores_codex":[0.9999014,0.000009906662,0.000009610432,0.00002445321,0.0000188981,0.00003566438],"domain_scores_gemma":[0.9998133,0.00001824247,0.00005382591,0.00001454132,0.00003112817,0.00006899397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01090342,0.001070183,0.04811717,0.002567671,0.0004840176,0.009978872,0.0005957159,0.001035987,0.7916397,0.008735417,0.002671095,0.1222007],"study_design_scores_gemma":[0.0005122716,0.003108583,0.75339,0.0003613251,0.0005249052,0.01073435,0.001004811,0.003695632,0.1810484,0.01485224,0.03065633,0.0001112872],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9210282,0.06642265,0.00324707,0.002994218,0.0003165068,0.00008290932,0.0007133064,0.00009767429,0.005097314],"genre_scores_gemma":[0.9640016,0.02989688,0.001440134,0.0002944922,0.0002375136,0.00004397978,0.0003521402,0.000005634046,0.003727586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001474478,"threshold_uncertainty_score":0.004932582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100668992669835,"score_gpt":0.2093100988970037,"score_spread":0.1992431996300202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}