{"id":"W7024267220","doi":"","title":"Safety, tolerability, and efficacy of PBT2 in Huntington's disease: A phase 2, randomised, double-blind, placebo-controlled trial","year":2015,"lang":"en","type":"article","venue":"Research Bank (Australian Catholic University)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Population; Cognition; Test (biology); Clinical endpoint; Cognitive test; Stroop effect","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001975298,0.0002907988,0.0007125121,0.001243224,0.0002256565,0.0001082741,0.0007287444,0.0001109346,0.00009489503],"category_scores_gemma":[0.003705583,0.0002945493,0.0002072652,0.001687937,0.0009898181,0.0003153837,0.0004186817,0.0005077863,0.00002481771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002175077,"about_ca_system_score_gemma":0.0009880286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001759118,"about_ca_topic_score_gemma":0.00004969631,"domain_scores_codex":[0.9941649,0.002444016,0.0005210713,0.0009532398,0.001119284,0.0007974649],"domain_scores_gemma":[0.9964855,0.001396032,0.0001729225,0.0006605135,0.0003218821,0.0009630962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9748769,0.001804453,0.0003455326,0.0000531151,0.00001753439,0.0002081389,0.00109272,0.0002920578,0.01997841,0.0007083981,0.0001332345,0.0004894764],"study_design_scores_gemma":[0.9339961,0.0007012123,0.0003516241,0.00004540486,0.00006533597,0.00000270866,0.0002640325,0.0001018349,0.05984719,0.00006937584,0.004296753,0.0002583951],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903443,0.00002453675,0.000008414608,0.00100249,0.0001164805,0.005698713,0.00007282463,0.00004068763,0.002691566],"genre_scores_gemma":[0.994593,0.00007446973,0.00003413059,0.00002027172,0.00009721075,0.00004054612,0.000009770652,0.00002513325,0.00510553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0408808,"threshold_uncertainty_score":0.9999506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1528434930098986,"score_gpt":0.3824122777755837,"score_spread":0.2295687847656852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}