{"id":"W7024387546","doi":"","title":"The role of innate polymorphisms in drug selected protease and reverse transcriptase mutations in HIV","year":2009,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Nuclear physics research studies","field":"Physics and Astronomy","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Cambridge; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Reverse transcriptase; Resistance mutation; RNase H; Mutation; Genotype; Drug resistance; Protease; Protease inhibitor (pharmacology); Innate immune system; Nucleoside Reverse Transcriptase Inhibitor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006442717,0.0002144647,0.0003046769,0.0002800379,0.000290949,0.001116339,0.0002463183,0.0002320921,0.00452205],"category_scores_gemma":[0.0005485433,0.0001271607,0.0001898229,0.000209995,0.0003105181,0.0003271486,0.000564787,0.0004770303,0.0005921603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003994309,"about_ca_system_score_gemma":0.0005772554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001753231,"about_ca_topic_score_gemma":0.0002256976,"domain_scores_codex":[0.9998243,0.00003723613,0.00001308993,0.00004322046,0.00004546425,0.00003675307],"domain_scores_gemma":[0.9996473,0.0001009459,0.00006722203,0.00002545442,0.0000736174,0.00008544696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001432137,0.0007900903,0.07417696,0.002399941,0.0001732919,0.001505913,0.003764904,0.006279914,0.4236979,0.03212453,0.008290593,0.4453638],"study_design_scores_gemma":[0.0002489797,0.00813746,0.292165,0.001744019,0.0004003592,0.005093293,0.004693172,0.008857888,0.4126005,0.04169106,0.2241601,0.0002081819],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9337873,0.03285165,0.006413465,0.003847309,0.0005878753,0.000118001,0.0005469745,0.00007547254,0.02177196],"genre_scores_gemma":[0.937028,0.02343842,0.005888714,0.0006165174,0.0003247673,0.0001260052,0.0004069708,0.00004240239,0.0321283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00452205,"threshold_uncertainty_score":0.01512778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007167749122389416,"score_gpt":0.2362814051829014,"score_spread":0.229113656060512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}