{"id":"W7028435209","doi":"","title":"Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.","year":2014,"lang":"en","type":"article","venue":"Arrow@dit (Dublin Institute of Technology)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; Instituto de Salud Carlos III; Menzies Centre for Australian Studies, King's College London, University of London; University of California, San Francisco; National Institutes of Health; Heinz Nixdorf Stiftung; Hjartavernd; H. Lundbeck A/S; Karl-Franzens-Universität Graz; University of Pennsylvania; Austrian Science Fund; Medizinische Universität Graz; Internationale Stichting Alzheimer Onderzoek; National Institute of Child Health and Human Development; Hersenstichting; Medical Research Council; Swedish Brain Power; National Institute of Neurological Disorders and Stroke; Llywodraeth Cymru; Deutsches Zentrum für Neurodegenerative Erkrankungen; National Heart, Lung, and Blood Institute; North Bristol NHS Trust; University of California, Davis; Vetenskapsrådet; University of Pittsburgh; Stockholms Läns Landsting; Marcus och Amalia Wallenbergs minnesfond; Erasmus Medisch Centrum; Bundesministerium für Bildung und Forschung; Karolinska Institutet; ZonMw; School of Medicine, Boston University; European Commission; Centro de Biología Molecular Severo Ochoa; Cardiff University; Alzheimer's Research Trust; University of California, Irvine; University College London Hospitals NHS Foundation Trust; University of California, Los Angeles; University of Washington; University of California, San Diego; Johns Hopkins University; National Institute on Deafness and Other Communication Disorders; Rush University; University of Miami; York University; Northwestern University; Ministero della Salute; Alzheimer's Society; National Institute for Health and Care Research; Alzheimer Society; Newcastle University; Vanderbilt University; Wellcome Trust; University of Southern California; Massachusetts General Hospital; Emory University; Juvenile Diabetes Research Foundation International","keywords":"Gene; Genetic association; Genotype; Disease; Immune system; Genomics; Genetic predisposition","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004926778,0.0003274925,0.0003552645,0.0009734418,0.0003587081,0.0006814889,0.000340884,0.0005471256,0.002430797],"category_scores_gemma":[0.00100453,0.0001892361,0.0004542293,0.0008885086,0.0003421851,0.0001382655,0.0004379737,0.0005716207,0.000356085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001552045,"about_ca_system_score_gemma":0.0001894768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000962229,"about_ca_topic_score_gemma":0.002195836,"domain_scores_codex":[0.9996166,0.00004955085,0.00002810128,0.0001898942,0.00006375011,0.00005202814],"domain_scores_gemma":[0.9993986,0.000250736,0.0001736568,0.00004444448,0.00004604803,0.00008639575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001324927,0.0001524187,0.8654398,0.0001037937,0.0008025551,0.001235041,0.0001938895,0.0003279223,0.1052602,0.0002962539,0.001021107,0.02384229],"study_design_scores_gemma":[0.00004534175,0.0001662707,0.9901321,0.000007599409,0.0003174574,0.001801171,0.00008258153,0.0004288968,0.005462899,0.0002487513,0.001298146,0.000008731414],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971278,0.0003490522,0.0007382877,0.00008425461,0.0000104044,0.00000983124,0.001070577,0.00003221914,0.000577426],"genre_scores_gemma":[0.9965119,0.00009792263,0.001330202,0.00009775599,0.00001280356,0.00001732877,0.001486069,0.000007977344,0.0004381048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002430797,"threshold_uncertainty_score":0.008131802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08972201066468717,"score_gpt":0.371510710954126,"score_spread":0.2817887002894388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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