{"id":"W7028435209","doi":"","title":"Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.","year":2014,"lang":"en","type":"article","venue":"Arrow@dit (Dublin Institute of Technology)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; Instituto de Salud Carlos III; Menzies Centre for Australian Studies, King's College London, University of London; University of California, San Francisco; National Institutes of Health; Heinz Nixdorf Stiftung; Hjartavernd; H. Lundbeck A/S; Karl-Franzens-Universität Graz; University of Pennsylvania; Austrian Science Fund; Medizinische Universität Graz; Internationale Stichting Alzheimer Onderzoek; National Institute of Child Health and Human Development; Hersenstichting; Medical Research Council; Swedish Brain Power; National Institute of Neurological Disorders and Stroke; Llywodraeth Cymru; Deutsches Zentrum für Neurodegenerative Erkrankungen; National Heart, Lung, and Blood Institute; North Bristol NHS Trust; University of California, Davis; Vetenskapsrådet; University of Pittsburgh; Stockholms Läns Landsting; Marcus och Amalia Wallenbergs minnesfond; Erasmus Medisch Centrum; Bundesministerium für Bildung und Forschung; Karolinska Institutet; ZonMw; School of Medicine, Boston University; European Commission; Centro de Biología Molecular Severo Ochoa; Cardiff University; Alzheimer's Research Trust; University of California, Irvine; University College London Hospitals NHS Foundation Trust; University of California, Los Angeles; University of Washington; University of California, San Diego; Johns Hopkins University; National Institute on Deafness and Other Communication Disorders; Rush University; University of Miami; York University; Northwestern University; Ministero della Salute; Alzheimer's Society; National Institute for Health and Care Research; Alzheimer Society; Newcastle University; Vanderbilt University; Wellcome Trust; University of Southern California; Massachusetts General Hospital; Emory University; Juvenile Diabetes Research Foundation International","keywords":"Gene; Genetic association; Genotype; Disease; Immune system; Genomics; Genetic predisposition","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003929568,0.0004583518,0.0009969042,0.001445617,0.000249559,0.00003491369,0.0005795028,0.0003109869,0.0001431635],"category_scores_gemma":[0.001307736,0.0004011614,0.000750148,0.002029802,0.0007848964,0.0002967266,0.0002167393,0.0002872072,0.0001220171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001207411,"about_ca_system_score_gemma":0.0007838428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002958182,"about_ca_topic_score_gemma":0.0008162896,"domain_scores_codex":[0.9968488,0.00004750306,0.0007010393,0.0009850307,0.000589953,0.0008277256],"domain_scores_gemma":[0.9962883,0.0001345547,0.0002920644,0.00188625,0.0005038269,0.0008949778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003437986,0.003006497,0.7214836,0.0004763131,0.09026524,0.0002034434,0.00006765174,0.0007377401,0.007157593,0.008120302,0.007848395,0.1571953],"study_design_scores_gemma":[0.04472289,0.004726036,0.1636452,0.0006809107,0.1099169,0.00009894255,0.0001891361,0.009651449,0.3246314,0.08160374,0.2564687,0.00366473],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709861,0.0125823,0.008451204,0.004941609,0.0003340312,0.001707087,0.000188991,0.0005284012,0.0002802314],"genre_scores_gemma":[0.9662158,0.0002871773,0.03219946,0.0001749506,0.000202159,0.0002167163,0.0005171156,0.00005083542,0.0001358165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5578384,"threshold_uncertainty_score":0.999844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08972201066468717,"score_gpt":0.371510710954126,"score_spread":0.2817887002894388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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