{"id":"W7029075479","doi":"","title":"Investigating translation in rodent neurons and in healthy and fragile X human induced pluripotent stem cell-derived neurons","year":2023,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Anadolu Üniversitesi; McGill University","keywords":"Induced pluripotent stem cell; Translation (biology); Rodent; Stem cell; Neuron","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002263413,0.0002447659,0.000192546,0.0004235806,0.0002602991,0.0003871337,0.0002610955,0.0002663336,0.00257539],"category_scores_gemma":[0.0001681458,0.0001600552,0.0003339827,0.0002737882,0.0002829093,0.0003533115,0.0002480881,0.0004333125,0.0005437324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005241125,"about_ca_system_score_gemma":0.0002711254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00164377,"about_ca_topic_score_gemma":0.003218596,"domain_scores_codex":[0.9998337,0.000008695817,0.00002460604,0.00005910883,0.0000459214,0.00002804585],"domain_scores_gemma":[0.99988,0.00001982389,0.0000372485,0.00001654955,0.00002451851,0.00002174572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009479887,0.00001759261,0.002010288,0.00007252141,0.00001831421,0.0002479488,0.00007183005,0.0001203992,0.9933549,0.0004256101,0.0001077037,0.00345799],"study_design_scores_gemma":[0.0000123323,0.0003712406,0.0415854,0.00002065301,0.00006498965,0.001183151,0.0002184972,0.0008189604,0.951013,0.0002701279,0.004431939,0.000009710169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837847,0.002479265,0.006779023,0.0001002941,0.00005066629,0.00005750268,0.002580238,0.0001132387,0.004055185],"genre_scores_gemma":[0.9751936,0.00216767,0.008453866,0.00008863077,0.00001219795,0.00008145777,0.003676006,0.000112034,0.01021459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00257539,"threshold_uncertainty_score":0.008615553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0276071202537934,"score_gpt":0.2547693000694664,"score_spread":0.2271621798156729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}