{"id":"W7029535475","doi":"","title":"Investigating the therapeutic effects of simvastatin on a mouse model of Rett syndrome","year":2024,"lang":"en","type":"dissertation","venue":"Mspace (University of Manitoba)","topic":"Medieval and Early Modern Justice","field":"Social Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Children's Hospital Research Institute of Manitoba; Ontario Rett Syndrome Association","keywords":"Simvastatin; Rett syndrome; Missense mutation; Phenotype; Statin; Therapeutic effect; Knockout mouse; Disease; Therapeutic approach; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004750843,0.0007347335,0.0009884924,0.0006525845,0.0004050749,0.0004521723,0.0006558338,0.001302795,0.002106554],"category_scores_gemma":[0.0002273594,0.0003028334,0.00105225,0.0002619787,0.0005446447,0.0005387862,0.0002763246,0.003052705,0.0006714861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000536875,"about_ca_system_score_gemma":0.0007110212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00129767,"about_ca_topic_score_gemma":0.001858111,"domain_scores_codex":[0.9995869,0.00005937545,0.0000498875,0.0001016225,0.00009277928,0.0001094173],"domain_scores_gemma":[0.9997185,0.00003538262,0.00006432323,0.0000226,0.0000406477,0.0001185641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002791181,0.001098803,0.0007088807,0.0002981141,0.00006897654,0.0003423196,0.0001124879,0.0002814378,0.9877939,0.0005168916,0.0006045159,0.005382576],"study_design_scores_gemma":[0.0008225433,0.01557013,0.005301448,0.0001021844,0.0004157909,0.0006152985,0.0003515995,0.002483999,0.9639706,0.000496966,0.009821855,0.00004756356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813921,0.005426692,0.004119065,0.001893371,0.0006414183,0.0002567548,0.002410286,0.0003468549,0.003513332],"genre_scores_gemma":[0.9673971,0.007441177,0.007713658,0.0007852137,0.0001198061,0.0008162337,0.002110889,0.00007433931,0.01354155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002106554,"threshold_uncertainty_score":0.007047117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02813184809553277,"score_gpt":0.24697931234384,"score_spread":0.2188474642483073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}