{"id":"W7033175783","doi":"","title":"Point Substitutions in G Protein-Coupled Receptors","year":2021,"lang":"en","type":"article","venue":"Scholarship@Western (Western University)","topic":"Legal case studies and regulations","field":"Social Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Allosteric regulation; Receptor; Point mutation; G protein-coupled receptor; Agonist; 5-HT5A receptor; Estrogen-related receptor alpha; Mutation; GABBR1; Binding site","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001002566,0.0002598612,0.00033526,0.0005432493,0.0009438297,0.0004930687,0.0004073189,0.001128918,0.007884368],"category_scores_gemma":[0.002293563,0.0001161127,0.0004012733,0.0006937562,0.0008022518,0.0003028758,0.0004285686,0.0007616538,0.001076266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000542056,"about_ca_system_score_gemma":0.0006063733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001101979,"about_ca_topic_score_gemma":0.001787658,"domain_scores_codex":[0.9990777,0.0002811235,0.0001081465,0.0001266506,0.0003284436,0.00007793864],"domain_scores_gemma":[0.9987825,0.0006393182,0.0002555849,0.0001223058,0.0001363977,0.00006386806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002399443,0.00106862,0.03467989,0.001588471,0.0004275883,0.09560837,0.00358389,0.008151398,0.4674179,0.1412246,0.03606401,0.207786],"study_design_scores_gemma":[0.0004545706,0.002316436,0.0594799,0.0007782714,0.0006429946,0.08575631,0.00245568,0.01406072,0.3536105,0.0361162,0.4439762,0.0003522527],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9278628,0.003236273,0.01879975,0.003052291,0.0009705106,0.0003776886,0.001964207,0.0005366962,0.04319987],"genre_scores_gemma":[0.9725158,0.001441054,0.01533288,0.0009215389,0.00008259821,0.0001294776,0.0007410015,0.0001044571,0.008731277],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.007884368,"threshold_uncertainty_score":0.02637577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08877729651569333,"score_gpt":0.334636850804111,"score_spread":0.2458595542884177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}