{"id":"W7033502492","doi":"","title":"Romidepsin enhances the efficacy of cytarabine in vivo, revealing histone deacetylase inhibition as a promising therapeutic strategy for KMT2A-rearranged infant acute lymphoblastic leukemia","year":2019,"lang":"en","type":"article","venue":"UWA Profiles and Research Repository (University of Western Australia)","topic":"Academic Publishing and Open Access","field":"Decision Sciences","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Global Health Research","funders":"","keywords":"Romidepsin; Histone deacetylase; Panobinostat; Cytarabine; Histone deacetylase inhibitor; Vorinostat; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004436644,0.0001568201,0.0004502028,0.0003723157,0.000380533,0.0002873681,0.0009710398,0.0002095238,0.0000503942],"category_scores_gemma":[0.0003687429,0.0001173434,0.0001186566,0.0006684141,0.0005877689,0.001066634,0.000270278,0.0004695698,0.000009875332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002005305,"about_ca_system_score_gemma":0.0004100665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004138863,"about_ca_topic_score_gemma":0.0001099542,"domain_scores_codex":[0.9966912,0.0006177923,0.0005161834,0.000554824,0.00121739,0.0004026396],"domain_scores_gemma":[0.9968991,0.001611309,0.000465959,0.0004298782,0.0004700575,0.0001236569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002054848,0.0001385201,0.02614176,0.0002616578,0.0001216164,0.00005105927,0.005604777,0.0006007537,0.9605519,0.000430405,0.001085643,0.002957067],"study_design_scores_gemma":[0.006122618,0.001366657,0.1939144,0.001548074,0.000127206,0.0001100306,0.02380731,0.004489924,0.7646595,0.002363384,0.0009675029,0.000523385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975712,0.0001744304,0.0001665601,0.0005240535,0.0001120274,0.00109222,0.00002614547,0.00001245448,0.0003208917],"genre_scores_gemma":[0.9880953,0.00005718231,0.0001485635,0.00001019578,0.00004691633,0.000004060972,0.000005448336,0.00001070447,0.01162163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1958924,"threshold_uncertainty_score":0.625675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1129084458824494,"score_gpt":0.4065854116834531,"score_spread":0.2936769658010037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}