{"id":"W7033636465","doi":"","title":"Quantitative detection of N7-and O6-methylguanine adducts by liquid chromatography and mass spectrometry in brain tumour tissues from patients treated with temozolomide","year":2012,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Education, Innovation and Language Studies","field":"Social Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Concordia University; McGill University","keywords":"Temozolomide; Mass spectrometry; High-performance liquid chromatography; Quantitative analysis (chemistry); Adduct; Liquid chromatography–mass spectrometry; Tumour tissue","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008566515,0.0004466199,0.0006570154,0.0007611818,0.0007347,0.00005649543,0.0001884189,0.0003870544,0.00030623],"category_scores_gemma":[0.001010567,0.000432594,0.00006656447,0.001531505,0.0002625328,0.0006774059,0.00003121454,0.0005243231,0.00000493245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002351527,"about_ca_system_score_gemma":0.00003978547,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01713167,"about_ca_topic_score_gemma":0.06311886,"domain_scores_codex":[0.9970773,0.0006082401,0.000644554,0.0006362089,0.0005849062,0.0004488293],"domain_scores_gemma":[0.9978346,0.0005155656,0.0007348805,0.0001976143,0.0005504719,0.0001668736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001851329,0.0009789236,0.0574038,0.0004816791,0.0009664698,0.00001117259,0.006307883,4.506115e-7,0.8863286,0.01936817,0.00003999702,0.02626155],"study_design_scores_gemma":[0.003145791,0.002015849,0.4184571,0.0009659078,0.0004210055,0.000001967921,0.08902451,0.000001851197,0.4714293,0.002423877,0.01030972,0.001803162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987965,0.002669162,3.878152e-7,0.00004695979,0.0002936121,0.0006186705,0.0006428119,0.00007922125,0.007684172],"genre_scores_gemma":[0.9968028,0.0006401456,0.0006753142,0.00005920547,0.00004197658,0.00007021448,0.0008752027,0.00006548808,0.0007696607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4148993,"threshold_uncertainty_score":0.9998126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350317954275597,"score_gpt":0.2813709121061705,"score_spread":0.2678677325634146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}