{"id":"W7034088370","doi":"","title":"S-Nitrosation of α-Ketoglutarate Dehydrogenase by MitoSNO mitigates oxidative stress as observed in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)","year":2025,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Mathematical Analysis and Transform Methods","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Jewish General Hospital; Lady Davis Institute for Medical Research; Universities Space Research Association; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Oxidative stress; Fatty liver; Disease; Dehydrogenase; Enzyme; Fatty acid; Oxidative phosphorylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00179001,0.001140182,0.002258375,0.0007471619,0.000530193,0.00009767582,0.0007076866,0.0009062641,0.0006916359],"category_scores_gemma":[0.007741172,0.001000949,0.001051745,0.00168667,0.00009482698,0.0006961056,0.00009197697,0.001340467,0.0000532179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003739356,"about_ca_system_score_gemma":0.0002086347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001068668,"about_ca_topic_score_gemma":0.003981222,"domain_scores_codex":[0.9926935,0.001602491,0.002375631,0.001258916,0.001260526,0.0008088826],"domain_scores_gemma":[0.9941295,0.001958301,0.001524915,0.0009040846,0.0008894856,0.0005936942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002915539,0.01121497,0.001542316,0.01649852,0.009953187,0.0002363077,0.0003317121,0.0001899158,0.1588837,0.7553537,0.00005866985,0.04282142],"study_design_scores_gemma":[0.002550416,0.0001344876,0.003124788,0.002749387,0.004187835,0.000001221331,0.0006435312,0.001131537,0.5375504,0.4456678,0.0007195898,0.001539053],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844328,0.001219967,0.00001734978,0.00002887185,0.0003126538,0.001475676,0.005911548,0.0001691607,0.006431986],"genre_scores_gemma":[0.9844497,0.0008811265,0.002798427,0.0001133912,0.00001980669,0.0004835069,0.005346171,0.0001814562,0.005726409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3786667,"threshold_uncertainty_score":0.9992441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03508016458735526,"score_gpt":0.2872141685768902,"score_spread":0.252134003989535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}