{"id":"W7034402289","doi":"","title":"Targeting Hedgehog Signalling as a Drug Therapy in Aggressive Fibromatosis","year":2012,"lang":"en","type":"dissertation","venue":"Library and Archives Canada (Government of Canada)","topic":"Intracranial Aneurysms: Treatment and Complications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Hedgehog signaling pathway; Aggressive fibromatosis; Hedgehog; Fibromatosis; Lesion; Signalling; Chemotherapy; Targeted therapy; Cell","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000103937,0.0001472578,0.0001681643,0.0003650505,0.0001674521,0.0002357062,0.0001016147,0.0001803962,0.001679934],"category_scores_gemma":[0.00005363553,0.00005955482,0.0001196846,0.0002364267,0.0001317935,0.00008721052,0.000113927,0.0003547567,0.0003433522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003656224,"about_ca_system_score_gemma":0.0004633605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002088425,"about_ca_topic_score_gemma":0.01055261,"domain_scores_codex":[0.9999707,0.000004618268,0.000002014903,0.00000257483,0.0000120325,0.000008046096],"domain_scores_gemma":[0.9999834,0.00000262242,0.000003175162,0.000001053102,0.000004070062,0.000005675343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001502577,0.001130762,0.001668829,0.001906711,0.00006484114,0.001071277,0.0003674405,0.0007658819,0.4205788,0.004505048,0.01053528,0.5559026],"study_design_scores_gemma":[0.0009458423,0.00892039,0.04216446,0.0008043827,0.0003133228,0.003916633,0.0003515663,0.001111567,0.3992235,0.001957843,0.5402341,0.00005642022],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.524205,0.4181003,0.002378784,0.002885516,0.0005169081,0.0002813143,0.0005354941,0.0001909642,0.05090566],"genre_scores_gemma":[0.6538489,0.2940853,0.004346041,0.000863583,0.0001867909,0.0001082766,0.000486597,0.00002086047,0.04605368],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002088425,"threshold_uncertainty_score":0.005619943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004364570233153622,"score_gpt":0.1792510903090609,"score_spread":0.1748865200759073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}