{"id":"W7034603383","doi":"","title":"Understanding the impact of uncertain mismatch repair-deficient results for individuals undergoing screening for Lynch syndrome","year":2023,"lang":"en","type":"dissertation","venue":"Mspace (University of Manitoba)","topic":"Mollusks and Parasites Studies","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Lynch syndrome; Genetic testing; Family history; Cohort; Colonoscopy; Colorectal cancer; DNA mismatch repair; Genetic counseling; Cohort study","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008501784,0.0001647429,0.0002654618,0.0009401404,0.002480702,0.002647933,0.0009364077,0.0007898852,0.00154492],"category_scores_gemma":[0.04005453,0.0003309639,0.0003886742,0.0007644763,0.001664084,0.001759117,0.002235667,0.001174071,0.0001145762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003733336,"about_ca_system_score_gemma":0.004831599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.06203092,"about_ca_topic_score_gemma":0.1333294,"domain_scores_codex":[0.9944795,0.003666608,0.0002749496,0.0002691314,0.0006938885,0.0006158895],"domain_scores_gemma":[0.9823576,0.01000293,0.004800388,0.0003679589,0.001169054,0.001302047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"qualitative","study_design_scores_codex":[0.0001060852,0.000116406,0.8787109,0.0001711097,0.00005177995,0.0008423058,0.102872,0.0000783032,0.0001848869,0.0005087241,0.001228009,0.01512953],"study_design_scores_gemma":[0.00001294192,0.0002354294,0.5974706,0.0006359467,0.00008068486,0.001315094,0.3936439,0.0005977739,0.0001545462,0.000952204,0.004862629,0.00003831404],"study_design_candidate":"qualitative","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906432,0.0009382561,0.0001515482,0.00599828,0.00002261489,0.00002779598,0.0001024791,0.000002759615,0.002113189],"genre_scores_gemma":[0.9981509,0.0005902842,0.0002618495,0.0008190918,0.00001327446,0.00001561722,0.0000342903,0.000001750808,0.0001128007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06203092,"threshold_uncertainty_score":0.1233397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1184422502429676,"score_gpt":0.2827175789827387,"score_spread":0.1642753287397711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}