{"id":"W7037276130","doi":"","title":"DMD Genotypes and Motor Function in Duchenne Muscular Dystrophy: A Multi-institution Meta-analysis With Implications for Clinical Trials","year":2023,"lang":"en","type":"article","venue":"UCL Discovery (University College London)","topic":"Hymenoptera taxonomy and phylogeny","field":"Agricultural and Biological Sciences","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Disability, Independent Living, and Rehabilitation Research; National Institute on Disability and Rehabilitation Research; Sanofi Genzyme; Italfarmaco; Hospital for Sick Children; University of Nottingham; Newcastle University; University of Oxford; University College London; University of Cambridge; Audentes Therapeutics; Great Ormond Street Hospital for Children; NHS Greater Glasgow and Clyde; Sarepta Therapeutics; Oxford University Hospitals NHS Foundation Trust; Astellas Pharma; FibroGen; Cytokinetics; Cambridge University Hospitals; Vertex Pharmaceuticals; University Hospitals Plymouth NHS Trust; National Institutes of Health; University Hospitals Birmingham NHS Foundation Trust; BioMarin Pharmaceutical; Daiichi Sankyo Europe; Gilead Sciences; National Institute for Health and Care Research; Parent Project Muscular Dystrophy; PTC Therapeutics; Eli Lilly and Company; U.S. Department of Defense; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Sanofi; Biogen; Pfizer; University Hospital Southampton NHS Foundation Trust; University Hospitals Bristol NHS Foundation Trust; Duchenne Parent Project; ZonMw; AveXis; GlaxoSmithKline","keywords":"Duchenne muscular dystrophy; Genotype; Clinical trial; Confounding; Ambulatory; Randomized controlled trial; Muscular dystrophy; Confidence interval","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.04926906,0.002760565,0.01454991,0.004448139,0.0009271469,0.004414127,0.003024382,0.002403726,0.003117414],"category_scores_gemma":[0.06257394,0.001715213,0.05164872,0.007864453,0.0007181263,0.002011446,0.002311099,0.00237773,0.0003119082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001701434,"about_ca_system_score_gemma":0.001712657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006069732,"about_ca_topic_score_gemma":0.007473019,"domain_scores_codex":[0.9525372,0.03542901,0.005151545,0.004230991,0.001725703,0.0009254326],"domain_scores_gemma":[0.9278502,0.05363846,0.007578744,0.007518569,0.002377738,0.001036211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.005426091,0.00001788656,0.03464181,0.006805196,0.9479372,0.0001114047,0.00002950802,0.001171252,0.0001485601,0.00009024444,0.0004604942,0.00316032],"study_design_scores_gemma":[0.001139451,0.0002390884,0.02174392,0.0009684844,0.9734817,0.00009317337,0.00003373013,0.001189662,0.00009763637,0.0003568837,0.0006278302,0.00002837348],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1412455,0.8409242,0.009832012,0.001477393,0.0006680373,0.0005308249,0.003821318,0.0003415275,0.001159137],"genre_scores_gemma":[0.9516191,0.03848179,0.005554499,0.0009800351,0.0003056662,0.0006511835,0.001849971,0.000152664,0.0004051097],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9854501,"threshold_uncertainty_score":0.2605628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1850711455839508,"score_gpt":0.3118871666568243,"score_spread":0.1268160210728735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}