{"id":"W7037712822","doi":"","title":"Evolutionary Alternatives on the Road to a New Specificity in a G Protein-Coupled Receptor","year":2017,"lang":"en","type":"dissertation","venue":"TSpace (University of Toronto)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Danmarks Grundforskningsfond; National Research Foundation","keywords":"G protein-coupled receptor; Receptor; Ligand (biochemistry); Regulator; Signal transduction; G protein; Functional selectivity; Plasma protein binding","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007405416,0.0002043206,0.0002880918,0.0001716368,0.0003469093,0.001504247,0.000330739,0.0004940604,0.001016677],"category_scores_gemma":[0.0003584114,0.0001595393,0.0003043758,0.0001559794,0.001235511,0.0009586388,0.0006320884,0.001570639,0.0003280099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005963607,"about_ca_system_score_gemma":0.0004460782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002647134,"about_ca_topic_score_gemma":0.0004998606,"domain_scores_codex":[0.9997482,0.0000736211,0.00001354155,0.00005000053,0.00006558089,0.00004907385],"domain_scores_gemma":[0.9998249,0.00005426438,0.00002314304,0.000031156,0.00002640882,0.00004004774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004372986,0.0001155948,0.002659053,0.0002519379,0.00005937102,0.001153005,0.0011126,0.003028941,0.7375186,0.2039017,0.00103333,0.04872859],"study_design_scores_gemma":[0.0001520074,0.001708013,0.01612982,0.0002627662,0.0002345873,0.004789566,0.003172476,0.01098899,0.5094427,0.1980612,0.2548754,0.0001823982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9265139,0.0166408,0.0263968,0.009671603,0.000249143,0.00001960808,0.00009261444,0.0001252152,0.0202903],"genre_scores_gemma":[0.9639218,0.01386266,0.01266006,0.001547626,0.00007556289,0.00001836648,0.00007979175,0.00004506162,0.007789002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001504247,"threshold_uncertainty_score":0.00432694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01520107749103138,"score_gpt":0.2525582571087772,"score_spread":0.2373571796177458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}