{"id":"W7038081123","doi":"","title":"Genetic drivers of heterogeneity in type 2 diabetes pathophysiology","year":2024,"lang":"en","type":"article","venue":"University of Southern Denmark Research Portal (University of Southern Denmark)","topic":"Military Technology and Strategies","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Janssen Research and Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Helmholtz Zentrum München; RIKEN; Respicardia; Manchester Biomedical Research Centre; Perelman School of Medicine, University of Pennsylvania; Regeneron Pharmaceuticals; Versus Arthritis; Medical Research Council; Tartu Ülikool; Servier; Technische Universität München; Quest Diagnostics; AstraZeneca; European Commission; Genentech; McMaster University; University of Oxford; Department of Health and Social Care; Guangdong Provincial People's Hospital; British Heart Foundation; Zora Biosciences; Ionis Pharmaceuticals; National Institutes of Health; ARCA Biopharma; Medicines Company; Vanderbilt University Medical Center; Hamilton Health Sciences; Queen Mary University of London; University of North Carolina at Chapel Hill; Harvard University; Novo Nordisk; U.S. Department of Veterans Affairs; University of Pennsylvania; Daiichi-Sankyo; Nanjing Medical University; Vanderbilt University; Yale University; Massachusetts General Hospital; Brigham and Women's Hospital; Imperial College London; U.S. Department of Health and Human Services; Abiomed; GlaxoSmithKline; Eli Lilly and Company; Pfizer; Amgen; American Heart Association; Broad Institute; Sanofi; National Center for Global Health and Medicine; National Institute for Health and Care Research; American Diabetes Association; Kowa Company","keywords":"Type 2 diabetes; Pathophysiology; Disease; Diabetes mellitus; Population; Identification (biology)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000571627,0.0003896834,0.0004435999,0.001415484,0.0004307533,0.001201018,0.0004821279,0.000735821,0.003455809],"category_scores_gemma":[0.002473682,0.0002931374,0.0004845599,0.001168065,0.0003269553,0.0004188342,0.0006920407,0.0005858799,0.0002137206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003049946,"about_ca_system_score_gemma":0.0003076847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002072712,"about_ca_topic_score_gemma":0.00129158,"domain_scores_codex":[0.9990968,0.0002740041,0.00008797241,0.000253336,0.0001393212,0.0001485158],"domain_scores_gemma":[0.998716,0.0004573052,0.0004498271,0.0001143567,0.00007655638,0.0001859867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003012767,0.0002308413,0.9267463,0.0001029503,0.001024741,0.002406424,0.0006552964,0.0007230924,0.04405177,0.003368315,0.0008366204,0.01684075],"study_design_scores_gemma":[0.00007741625,0.0001585039,0.9870512,0.00006018498,0.0004182163,0.002245029,0.0005750718,0.001035903,0.003215282,0.003524565,0.001600115,0.00003845332],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974024,0.0006611216,0.0004114043,0.0002100907,0.00002114861,0.000008015814,0.0003552464,0.000009590774,0.0009209761],"genre_scores_gemma":[0.9988655,0.0002063449,0.0002778221,0.00004426705,0.00002633139,0.000005782629,0.0002385533,0.000008855378,0.0003265124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003455809,"threshold_uncertainty_score":0.01156086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497515498480351,"score_gpt":0.2180739340766288,"score_spread":0.2030987790918253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}