{"id":"W7046785324","doi":"","title":"Electrophysiological assessment of two potential hERG correctors","year":2017,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Magnetic confinement fusion research","field":"Physics and Astronomy","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"McGill University","keywords":"hERG; Potassium channel; Gating; Electrophysiology; Patch clamp; Long QT syndrome; Potassium channel blocker; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002540454,0.0003066504,0.0003037248,0.0001436646,0.00009762609,0.0002228473,0.000261912,0.000638883,0.001392915],"category_scores_gemma":[0.0004749181,0.00007583429,0.0001632127,0.00009907012,0.0001385866,0.0002615831,0.0001503298,0.0003056515,0.000260484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000111798,"about_ca_system_score_gemma":0.0000809461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001554081,"about_ca_topic_score_gemma":0.0001728164,"domain_scores_codex":[0.9997793,0.00003236473,0.00002740785,0.00005047988,0.00006307584,0.00004747349],"domain_scores_gemma":[0.9997432,0.00008222611,0.00003969814,0.00002574481,0.00007088117,0.00003822906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001058437,0.00003248182,0.0002244283,0.00002224087,0.000004829281,0.00007405427,0.00001010911,0.0000458648,0.9977912,0.00002203963,0.00001795538,0.001648899],"study_design_scores_gemma":[0.00004273198,0.00189643,0.00958978,0.000007191285,0.00002920116,0.0004235351,0.00005505251,0.002196454,0.9847699,0.00005135526,0.0009314597,0.000006963999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914687,0.000858626,0.006348349,0.00007680803,0.00004758896,0.0000590978,0.0002465661,0.000100996,0.0007933461],"genre_scores_gemma":[0.9944943,0.0005419735,0.003287369,0.0000630799,0.00001079274,0.00005883041,0.0003042972,0.00001618458,0.001223264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001392915,"threshold_uncertainty_score":0.004659712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01419849278182804,"score_gpt":0.3011658787205678,"score_spread":0.2869673859387397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}