{"id":"W7047149943","doi":"","title":"Emergence of Nelfinavir and Lopinavir resistance relative to a clinically relevant human immunodeficiency virus type-1 single nucleotide polymorphism at position 36 in protease enzyme «in vitro»","year":2010,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Magnetic confinement fusion research","field":"Physics and Astronomy","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"McGill University","keywords":"Lopinavir; Nelfinavir; Protease; Isoleucine; Single-nucleotide polymorphism; Enzyme; Methionine; Virus; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000192017,0.0001504387,0.0001632079,0.000127621,0.0001415831,0.0002402078,0.0001469155,0.0001856853,0.00297324],"category_scores_gemma":[0.000264507,0.0000833321,0.0001823835,0.00009247218,0.0001156268,0.00006833725,0.00007021315,0.0003945553,0.0003829793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002386566,"about_ca_system_score_gemma":0.0001533303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007600674,"about_ca_topic_score_gemma":0.00102283,"domain_scores_codex":[0.9998199,0.00005147446,0.00001335876,0.00003833137,0.00003503544,0.00004195041],"domain_scores_gemma":[0.9998978,0.00004008321,0.00001713757,0.00001199537,0.00001048598,0.00002246668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009640948,0.000265619,0.004806695,0.0000617339,0.00001935984,0.0003072991,0.00005840659,0.0001423196,0.9746894,0.0002693329,0.0005135375,0.01790219],"study_design_scores_gemma":[0.0001191663,0.005459465,0.1142914,0.0000264004,0.00005747687,0.003722007,0.000108446,0.001106382,0.863665,0.0002667775,0.01115412,0.00002346553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933171,0.001790973,0.000412591,0.0001424832,0.00005508232,0.00003483411,0.000450533,0.00002048274,0.003775898],"genre_scores_gemma":[0.9937238,0.0008858609,0.0006208357,0.0001337316,0.00002129915,0.0000202809,0.0005467375,0.000005707016,0.004041733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00297324,"threshold_uncertainty_score":0.009946465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01563866862017991,"score_gpt":0.27909077354829,"score_spread":0.2634521049281101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}