{"id":"W7047703786","doi":"","title":"A HUMAN IN VITRO INVESTIGATION OF THE AUTISM SPECTRUM DISORDER RISK GENE SCN2A","year":2022,"lang":"en","type":"dissertation","venue":"MacSphere (McMaster University)","topic":"Lightning and Electromagnetic Phenomena","field":"Physics and Astronomy","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Phenotype; Gene; Sodium channel; Autism spectrum disorder; SCN3A; Candidate gene; Disease; Neurodevelopmental disorder; Exome sequencing","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005601763,0.000289063,0.0003337564,0.0001763186,0.0003144484,0.0004372586,0.0003598296,0.0004252671,0.002045839],"category_scores_gemma":[0.0004409241,0.0002039731,0.000382828,0.0002620926,0.000237112,0.0001600265,0.0003289312,0.0005256487,0.001225065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004508989,"about_ca_system_score_gemma":0.0003321739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002986755,"about_ca_topic_score_gemma":0.004155877,"domain_scores_codex":[0.9993931,0.0001816968,0.00006218713,0.0001410729,0.0001563885,0.00006546083],"domain_scores_gemma":[0.9998024,0.00007867321,0.0000158539,0.00004944247,0.00003809129,0.00001546439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000111787,0.00005546915,0.0007558365,0.0001166932,0.00002577556,0.0003328933,0.00009255952,0.0004043472,0.9945903,0.0006225277,0.0005155748,0.002376264],"study_design_scores_gemma":[0.0000768704,0.001073705,0.009223561,0.000072394,0.0001369655,0.002453205,0.0002860934,0.008029982,0.9188908,0.0006282934,0.05909821,0.00002995911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9310286,0.01145619,0.02873442,0.001444764,0.0006431802,0.0002351483,0.006301279,0.000206065,0.0199503],"genre_scores_gemma":[0.9566244,0.005579062,0.01936137,0.0005629572,0.00005863905,0.0001439816,0.008850979,0.0001003632,0.008718208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002986755,"threshold_uncertainty_score":0.006844044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004822299259159868,"score_gpt":0.1813420597788304,"score_spread":0.1765197605196706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}