{"id":"W7049032525","doi":"","title":"Models of Neuroimaging, Biomarkers, and Cognitive in Alzheimer's Disease. Implications for Clinical Trial Design.","year":2021,"lang":"en","type":"article","venue":"Lund University Publications (Lund University)","topic":"Superconducting and THz Device Technology","field":"Physics and Astronomy","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; University of California, San Diego; National Institutes of Health; National Institute of Mental Health; Stiftelsen Bundy Academy; IXICO; Genentech; Marcus och Amalia Wallenbergs minnesfond; Skånes universitetssjukhus; Sveriges Läkarförbund; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Greta och Johan Kocks stiftelser; Vetenskapsrådet; Eisai; Lunds Universitet; Northern California Institute for Research and Education; Danone; Servier; Knut och Alice Wallenbergs Stiftelse; Pfizer; Biogen; BioClinica; Gyllenstiernska Krapperupsstiftelsen; Australian Government; F. Hoffmann-La Roche; Synarc; University of Southern California; Medpace; Dementia Collaborative Research Centres, Australia; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Alzheimer's Disease Neuroimaging Initiative; Medical Research Council; Meso Scale Diagnostics; Science and Industry Endowment Fund; Alzheimer's Association","keywords":"Nucleofection; Gestational period; TSG101; Dysgeusia; Diafiltration; Liquation; Emperipolesis; Triacetin; Durvalumab","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06830754,0.002075752,0.003954425,0.001183317,0.0006446286,0.004136442,0.002730414,0.002667688,0.008728283],"category_scores_gemma":[0.09747843,0.001263854,0.003805892,0.001349491,0.001709735,0.002692795,0.00138497,0.002846528,0.0009985793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002284691,"about_ca_system_score_gemma":0.007305485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003468887,"about_ca_topic_score_gemma":0.004959614,"domain_scores_codex":[0.9595629,0.03676223,0.000863091,0.001191743,0.001129347,0.0004907082],"domain_scores_gemma":[0.9276105,0.06306606,0.004370203,0.002512834,0.001422347,0.001017949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0843989,0.003086444,0.04014621,0.01385269,0.04148057,0.0006533013,0.0006629846,0.09526297,0.002110624,0.3384279,0.06037991,0.3195376],"study_design_scores_gemma":[0.04681652,0.01405011,0.01863413,0.003830008,0.03754811,0.0007338895,0.0003057947,0.2123149,0.001622758,0.6172734,0.04651317,0.0003571555],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1533171,0.2130565,0.4275798,0.1104633,0.0160263,0.02063482,0.02173384,0.001752261,0.03543612],"genre_scores_gemma":[0.7599798,0.0358603,0.1352096,0.008836339,0.003559761,0.03947204,0.003822311,0.000176378,0.01308352],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.06830754,"threshold_uncertainty_score":0.3612491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1261955253404495,"score_gpt":0.323007803966715,"score_spread":0.1968122786262655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}