{"id":"W7049077975","doi":"","title":"Nephrin missense mutations altez cellular trafficking and induce endoplasmic retioulum stress","year":2012,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Magnetic confinement fusion research","field":"Physics and Astronomy","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Nephrin; Endoplasmic reticulum; Unfolded protein response; HEK 293 cells; Mutant; Immunoprecipitation; ER retention; Mutant protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009143077,0.0004377459,0.0002462577,0.0002145739,0.0001395579,0.000184445,0.0001501906,0.0004282056,0.00194631],"category_scores_gemma":[0.0001586497,0.0001584577,0.000446629,0.0001475858,0.0002502302,0.0001011979,0.000253117,0.0004079008,0.0005816654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002558727,"about_ca_system_score_gemma":0.0001750215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007024746,"about_ca_topic_score_gemma":0.001116029,"domain_scores_codex":[0.9998399,0.00002318158,0.00002617537,0.00003213099,0.00005060972,0.00002789651],"domain_scores_gemma":[0.9998482,0.0000243108,0.00005747254,0.00001632288,0.00001406141,0.00003958832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001111999,0.0000245245,0.0004236079,0.00002524635,0.00001253612,0.0008974393,0.00001637603,0.00006249724,0.9974107,0.00007462705,0.00008038676,0.0008608358],"study_design_scores_gemma":[0.00004934551,0.0003546487,0.0174624,0.00001033806,0.00004177082,0.004594438,0.00005306344,0.00114943,0.9726171,0.00006939038,0.003585607,0.00001239599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974426,0.0002787381,0.0009491462,0.00006013773,0.00003866119,0.00002011584,0.0003665816,0.0001333704,0.0007107414],"genre_scores_gemma":[0.994813,0.0003932411,0.001032147,0.0000770974,0.00001182937,0.00002875978,0.0006314089,0.0000639536,0.002948533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00194631,"threshold_uncertainty_score":0.006511033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01407337323154456,"score_gpt":0.2445141053101616,"score_spread":0.230440732078617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}